Development of a radiomics-based method for predicting improvement of upper and lower limb motor function after revascularization

2024 Fiscal Year Final Research Report

• Project/Area Number: 21K16638
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Iwate Medical University
• Principal Investigator: Sato Shinpei 岩手医科大学, 医学部, 非常勤医師 (80882282)
• Project Period (FY): 2021-04-01 – 2025-03-31
• Keywords: 頚動脈内膜剥離術 / IMZ-SPECT / ARAT / 歩行分析計 / radiomics

Outline of Final Research Achievements

In this study, we aimed to clarify the mechanism of integrated motor control in the cerebrum by performing radiomics analysis (a comprehensive analysis that associates biological information of the lesion with a large number of quantitative features extracted from medical images) combining lower limb motor function and 123Iomazenil single photon emission computed tomography (IMZ-SPECT) with objective evaluation of upper limb motor function in patients with internal carotid artery stenosis. As a result of the study, it was revealed that Brodman areas 4 and 6, which indicate brain function localization, are related to improvement of upper limb motor function.

Free Research Field

脳循環代謝

Academic Significance and Societal Importance of the Research Achievements

本研究の成果から、今後、123Iomazenil single photon emission computed tomography（IMZ-SPECT）の早期像・晩期像を利用することで、頚動脈内膜剥離術前後の運動機能改善が推測できるシステムの開発が期待できる。