Development of a novel treatment for oral cancer with Plasma-activated Ringer's Lactate Solution

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K21008
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Nagoya University
• Principal Investigator: Sato Kotaro 名古屋大学, 医学系研究科, 助教 (00908808)
• Project Period (FY): 2021-08-30 – 2023-03-31
• Keywords: 口腔癌 / フェロトーシス / コラーゲン / プラズマ

Outline of Final Research Achievements

Plasma-activated Ringer’s lactate solution (PAL) treatment killed OSCC cells more effectively than control non-tumorous cells and suppressed cell migration and invasion. The type of cell death was ferroptosis. After applying PAL, the protein level of LOX was decreased in cancer cells in vitro and in vivo. Additionally, PAL improved the survival rate and suppressed collagenous matrix formation.

Free Research Field

口腔癌

Academic Significance and Societal Importance of the Research Achievements

プラズマ活性乳酸リンゲル液は口腔癌細胞に対してフェロトーシスを引き起こし，さらにコラーゲンおよびコラーゲンクロスリンクの形成を抑制することで転移を抑制させる可能性が示唆された．PALが口腔癌に対して副作用が少なく，効果的な治療方法であることが客観的に示され，今後の臨床研究への橋渡しとして重要な結果が得られたと考える．