Development of experimentation systems related to personalized medicine using humanized NOG mice

2014 Fiscal Year Final Research Report

• Project/Area Number: 22220007
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Laboratory animal science
• Research Institution: Central Institute for Experimental Animals
• Principal Investigator: ITO Mamoru 公益財団法人実験動物中央研究所, その他部局等, 研究員 (00176364)
• Co-Investigator(Kenkyū-buntansha): ANDO Kiyoshi 東海大学, 医学部, 教授 (70176014) ; KOYANAGI Yoshio 京都大学, ウイルス研究所, 教授 (80215417) ; KAMETANI Yoshie 東海大学, 医学部, 准教授 (50338787) ; TAKAHASI Takeshi 東北大学, 医学研究科, 助教 (80335215)
• Co-Investigator(Renkei-kenkyūsha): NAKAHATA Tatsutoshi 京都大学, iPS細胞研究所, 教授 (20110744) ; YAHATA Takashi 東海大学, 医学部, 准教授 (10398753) ; SUEMIZU Hiroshi 公益財団法人実験動物中央研究所, 主任研究員 (40332209) ; ETO Tomoo 公益財団法人実験動物中央研究所, 研究員 (30370175)
• Research Collaborator: ITO Ryoji ; KATANO Ikumi
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: ヒト化マウス / 免疫不全マウス / 実験動物学 / 個別医療

Outline of Final Research Achievements

Humanized mice in which human cells and tissues are successfully engrafted and act as in human being are extremely useful to analyze the biology of human and to develop drugs to human diseases. In this project, we attempted to develop various severely immunodeficient mice appropriate for generating humanized mice and various humanized mouse models. For the 5-year study period, we have successfully developed 87 different immunodeficient mouse strains for humanized mouse models. Using these strains, we successfully developed human allergy models, infectious disease models such as HIV-1 and EBV and human cancer models. In the study for individual medicine, we have developed NOG mouse strains expressing different HLA types, but the development of artificial thymus and hematopoietic stem cells from pluripotent stem cells such as ES and iPS cells was not completed in this period.

Free Research Field

実験動物学