2013 Fiscal Year Final Research Report
Study of MT1-MMP in cancer
| Project/Area Number |
22220014
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SEIKI Motoharu 東京大学, 医科学研究所, 名誉教授 (10154634)
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| Co-Investigator(Kenkyū-buntansha) |
FUKADA Satoshi 高知大学, 教育研究部医療学系, 助教 (80527599)
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| Co-Investigator(Renkei-kenkyūsha) |
KOSHIKAWA Naohiko 東京大学, 医科学研究所, 准教授 (70334282)
SAKAMOTO Takeharu 東京大学, 医科学研究所, 助教 (70511418)
HOSHINO Daisuke 東京大学, 医科学研究所, 助教 (30571434)
SYUUO Takuya 東京大学, 医科学研究所, 特任研究員 (90399006)
NAGANO Makoto 摂南大学, 薬学部, 助教 (50572715)
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| Project Period (FY) |
2010-05-31 – 2014-03-31
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| Keywords | がん / 浸潤・転移 / 腫瘍形成 / プロテアーゼ / MT1-MMP / コラーゲン / HB-EGF / HIF-1 |
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| Research Abstract |
Cancer cells are usually destructive against surrounding tissue and this activity is necessary for the cells to continue grow abnormally, invade and form metastatic tumor nodules. Cancer cells also alter the tumor microenvironment by producing different tissue constituents from the normal ones and by changing the integrity of extracellular proteins via protein processing. Degradation and processing of proteins in the tissue space are mediated by extracellular proteases. Membrane type 1 matrix metalloproteinase (MT1-MMP) is one of such extracellular proteases expressed in cancer cells. In this study, we analyzed multidimensional functions of MT1-MMP and their coordinated action with intracellular systems regulating cell growth and invasion. The results suggest that MT1-MMP is important acting as a nordal point regulator during acquisition of malignant phenotype of cancer cells.
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Research Products
(38 results)
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[Journal Article] Hypoxia-inducible factor 1 regulation through cross talk between mTOR and MT1-MMP2014
Author(s)
Sakamoto, T., Weng, J. S., Hara, T., Yoshino, S., Kozuka-Hata, H., Oyama, M., and Seiki, M
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Journal Title
Mol Cell Biol
Volume: 34(1)
Pages: 30-42
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[Journal Article] Hepatocyte growth factor activator inhibitor type 1 is a suppressor of intestinal tumorigenesis2013
Author(s)
Hoshiko, S., Kawaguchi, M., Fukushima, T., Haruyama, Y., Yorita, K., Tanaka, H., Seiki, M., Inatsu, H., Kitamura, K., and Kataoka, H
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Journal Title
Cancer Res
Volume: 73(8)
Pages: 2659-70
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[Journal Article] The phosphoinositide-binding protein ZF21 regulates ECM degradation by invadopodia2013
Author(s)
Hoshino, D., Nagano, M., Saitoh, A., Koshikawa, N., Suzuki, T., and Seiki, M
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Journal Title
PLos One
Volume: 8(1)
Pages: e50825
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[Journal Article] Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β12013
Author(s)
Mori, H., Lo, A. T., Inman, J. L., Alcaraz, J., Ghajar, C. M., Mott, J. D., Nelson, C. M., Chen, C. S., Zhang, H., Bascom, J. L., Seiki, M., and Bissell, M. J
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Journal Title
Development
Volume: 140(2)
Pages: 343-52
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[Journal Article] MT1-MMP-dependent control of skeletal stem cell commitment via a beta 1-integrin/YAP/TAZ signaling axis2013
Author(s)
Tang, Y., Rowe, R. G., Botvinick, E. L., Kurup, A., Putnam, A. J., Seiki, M., Weaver, V. M., Keller, E. T., Goldstein, S., Dai, J., Begun, D., Saunders, T., and Weiss, S. J
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Journal Title
Dev Cell
Volume: 25(4)
Pages: 402-16
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[Journal Article] Critical role of transient activity of MT1-MMP for ECM degradation in invadopodia2013
Author(s)
Watanabe, A., Hoshino, D., Koshikawa, N., Seiki, M., Suzuki, T., and Ichikawa, K
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Journal Title
PLos Comput Biol
Volume: 9(5)
Pages: e1003086
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[Journal Article] Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCalpha invasive signaling axis2012
Author(s)
Hoshino, D., Jourquin, J., Emmons, S. W., Miller, T., Goldgof, M., Costello, K.Tyson, D. R., Brown, B., Lu, Y., Prasad, N. K., Zhang, B., Mills, G. B., Yarbrough, W. G., Quaranta, V., Seiki, M., and Weaver, A. M
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Journal Title
Sci Signal
Volume: 5(241)
Pages: ra66
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[Journal Article] The proteolytic activity of MT4-MMP is required for its pro-angiogenic and pro-metastatic promoting effects2012
Author(s)
Host, L., Paye, A., Detry, B., Blacher, S., Munaut, C., Foidart, J. M., Seiki, M., Sounni, N. E., and Noel, A
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Journal Title
Int. J Cancer
Volume: 131(7)
Pages: 1537-48
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[Journal Article] MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells2012
Author(s)
Nishida, C., Kusubata, K., Tashiro, Y., Gritli, I., Sato, A., Ohki-Koizumi, M., Morita, Y., Nagano, M., Sakamoto, T., Koshikawa, N., Kuchimaru, T., Kizaka-Kondoh, S., Seiki, M., Nakauchi, H., Heissig, B., and Hattori, K
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Journal Title
Blood
Volume: 119(23)
Pages: 5405-16
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[Journal Article] Control and inhibition analysis of complex formation processes2012
Author(s)
Saitou, T., Itano, K., Hoshino, D., Koshikawa, N., Seiki, M., Ichikawa, K., and Suzuki, T
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Journal Title
Theor Biol Med Model
Volume: 9
Pages: 33
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[Journal Article] Detection of the heterogeneous O-glycosylation profile of MT1-MMP expressed in cancer cells by a simple MALDI-MS method2012
Author(s)
Shuo, T., Koshikawa, N., Hoshino, D., Minegishi, T., Ao-Kondo, H., Oyama, M., Sekiya, S., Iwamoto, S., Tanaka, K., and Seiki, M
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Journal Title
PLos One
Volume: 7(8)
Pages: e43751
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[Journal Article] Identification of proteins that associate with integrin alpha2 by proteomic analysis in human fibrosarcoma HT-1080 cells2012
Author(s)
Uematsu, T., C. Konishi, D. Hoshino, X. Han, Taizotomari, N. Egawa, Y. Takada, T. Isobe, M. Seiki, and N. Koshikawa
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Journal Title
J Cell Physiol
Volume: 8
Pages: 3072-9
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[Journal Article] ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain2010
Author(s)
Nagano, M., D. Hoshino, S. Koshiba, T. Shuo, N. Koshikawa, T. Tomizawa, F. Hayashi, N. Tochio, T. Harada, T. Akizawa, S. Watanabe, N. Handa, M. Shirouzu, T. Kigawa, S. Yokoyama, and M. Seiki
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Journal Title
J Biol Chem
Volume: 286(36)
Pages: 31598-609
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