環境ストレスによるヌクレオチドプールの恒常性破綻の分子病態と制御機構の解明

2013 Fiscal Year Annual Research Report

• Project/Area Number: 22221004
• Research Institution: Kyushu University
• Principal Investigator: 中別府 雄作 九州大学, 生体防御医学研究所, 教授 (30180350)
• Co-Investigator(Kenkyū-buntansha): 作見 邦彦 九州大学, 生体防御医学研究所, 准教授 (50211933) ; 土本 大介 九州大学, 生体防御医学研究所, 助教 (70363348) ; 盛 子敬 九州大学, 学内共同利用施設等, 助教 (90467895) ; 秋本 頼子 九州大学, 生体防御医学研究所, 研究員 (50613254)
• Project Period (FY): 2010-05-31 – 2015-03-31
• Keywords: ヌクレオチドプール / 環境ストレス / 化学物質 / 放射線 / 病態モデル / 酸化ヌクレオチド / 脱アミノ化ヌクレオチド / DNA修復

Research Abstract

環境ストレスによるヌクレオチドプールの恒常性破綻が引き起こす生体障害について以下の成果を挙げた。
① 2-ヒドロキシアデノシン（2-OH-Ado）は、細胞内に取り込まれるとアデノシンキナーゼ（ADK）により2-OH-ATPに変換され，細胞増殖の抑制とカスペース依存性のアポトーシスを誘導することがわかった。② ITPA欠損細胞はDNA中にデオキシイノシン（dIno）を蓄積し、細胞増殖を抑制する。DNAおよびRNA中のdIno/Ino除去酵素endonuclease V (EndoV)，あるいはヒポキサンチンDNAグリコシラーゼ活性を持つmethyl purin DNA glycosylase (MPG)の欠損はITPA欠損の表現型を増悪したが、ミスマッチ修復酵素（MLH1）欠損は細胞増殖抑制を回避することが明らかになった。③ X線を頭部に限定して照射したOGG1/MTH1二重欠損マウスにおいて、野生型では見られない自発運動の低下と海馬神経細胞突起に顕著な8-oxoGの蓄積を認めた。④ MTH1/OGG1二重欠損マウスは寿命、発がん頻度ともに野生型マウスと差が認められなかったが，MTH1/OGG1/MUTYH三重欠損マウスでは生後50日からがん死が認められ、多様な臓器における自然発がんと寿命の短縮を認めた。OGG1/MUTYH二重欠損マウスでは、三重欠損マウスに比較して有意な寿命の延長と発がん頻度の低下が認められた。⑤ MTH1/OGG1/MUTYH三重欠損マウスの生殖細胞系列において、G:CからT:Aへの突然変異が野生型の200倍以上の頻度で生じ，さまざまな変異形質をもたらすことが明らかになった。⑥ アルツハイマー病のモデル（3xTg-AD）マウスにMTH1/OGG1の二重欠損を導入したところ認知機能の早期障害を認めた。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

① ATPの酸化体の2-OH-ATPによる新たな細胞障害機構、② dATPの脱アミノ化体であるdITPによる細胞増殖阻害、③ 放射線の脳照射によって誘発される行動異常のMTH1とOGG1による抑制、④ 8-oxo-dGTPが体細胞ならびに生殖細胞系列の自然突然変異の主要な原因であることを証明、⑤ アルツハイマー病における酸化ヌクレオチドの関与を示唆するなど、当初の目的をほとんど達成するとともに、アルツハイマー病におけるヌクレオチドプール恒常性維持機構の重要性を示すなど世界をリードする独創的な成果が得られつつある。

Strategy for Future Research Activity

老化に伴う酸化ストレスなど、内的環境ストレスがアルツハイマー病の進展に関与することが強く示唆される結果が得られており、具体的にヌクレオチドプールの恒常性破綻がどの程度アルツハイマー病の進展に関与するのか、詳細を明らかにできると考えている。わが国でも高齢者人口の急速な増加とともに認知症患者も増加しており、厚生労働省の推計によればその数は現在500万人を越える可能性があるといわれている。予防、早期治療を含めた総合的な対策を講じてこの老年期認知症の増加に歯止めをかけることは、わが国の医療行政における焦眉の課題である。ヌクレオチドプールの恒常性破綻によるアルツハイマー病の進展の機序を解明することで、この社会問題の解決に貢献したい。

Research Products

• [Journal Article] Inhibitory effects of dietary Spirulina platensis on UVB induced skin inflammatory responses and carcinogenesis. (2014)
  • Author(s): Yogianti, F., Kunisada, M., Nakano, E., Ono, R., Sakumi, K., Oka, S., Nakabeppu, Y., and Nishigori, C.
  • Journal Title: J Invest Dermatol Volume: N/A Pages: N/A
  • DOI: 10.1038/jid.2014.188
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• [Journal Article] DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3beta and expressions of cyclin D1 and TCF7L2 in cancer model mice. (2014)
  • Author(s): Takahashi-Yanaga, F., Yoshihara, T., Jingushi, K., Igawa, K., Tomooka, K., Watanabe, Y., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., and Sasaguri, T.
  • Journal Title: Biochem Pharmacol Volume: N/A Pages: N/A
  • DOI: 10.1016/j.bcp.2014.03.006
  • Peer Reviewed
• [Journal Article] 8-oxoguanine causes spontaneous de novo germline mutations in mice. (2014)
  • Author(s): Ohno, M., Sakumi, K., Fukumura, R., Furuichi, M., Iwasaki, Y., Hokama, M., Ikemura, T., Tsuzuki, T., and Nakabeppu, Y.
  • Journal Title: Sci Rep Volume: 4 Pages: 4689
  • DOI: 10.1038/srep04689
  • Peer Reviewed
• [Journal Article] Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia. (2014)
  • Author(s): Nomaru, H., Sakumi, K., Katogi, A., Ohnishi, Y.N., Kajitani, K., Tsuchimoto, D., Nestler, E.J., and Nakabeppu, Y.
  • Journal Title: Glia Volume: N/A Pages: N/A
  • DOI: 10.1002/glia.22680
  • Peer Reviewed
• [Journal Article] Mice heterozygous for the xanthine oxidoreductase gene facilitate lipid accumulation in adipocytes. (2014)
  • Author(s): Murakami, N., Ohtsubo, T., Kansui, Y., Goto, K., Noguchi, H., Haga, Y., Nakabeppu, Y., Matsumura, K., and Kitazono, T.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 34 Pages: 44-51
  • DOI: 10.1161/ATVBAHA.113.302214
  • Peer Reviewed
• [Journal Article] Galectin-1 deficiency improves axonal swelling of motor neurons in SOD1 transgenic mice. (2014)
  • Author(s): Kobayakawa, Y., Sakumi, K., Kajitani, K., Kadoya, T., Horie, H., Kira, J.I., and Nakabeppu, Y.
  • Journal Title: Neuropathol Appl Neurobiol Volume: N/A Pages: N/A
  • DOI: 10.1111/nan.12123
  • Peer Reviewed
• [Journal Article] Characterization of galectin-1-positive cells in the mouse hippocampus. (2014)
  • Author(s): Kajitani, K., Kobayakawa, Y., Nomaru, H., Kadoya, T., Horie, H., and Nakabeppu, Y.
  • Journal Title: Neuroreport Volume: 25 Pages: 171-176
  • DOI: 10.1097/WNR.0000000000000068
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• [Journal Article] Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage. (2014)
  • Author(s): Jalland, C.M., Benestad, S.L., Ersdal, C., Scheffler, K., Suganthan, R., Nakabeppu, Y., Eide, L., Bjoras, M., and Tranulis, M.A.
  • Journal Title: Free Radic Biol Med Volume: 68 Pages: 1-7
  • DOI: 10.1016/j.freeradbiomed.2013.11.013
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• [Journal Article] Down-regulation of MET in hippocampal neurons of Alzheimer's disease brains. (2014)
  • Author(s): Hamasaki, H., Honda, H., Suzuki, S.O., Hokama, M., Kiyohara, Y., Nakabeppu, Y., and Iwaki, T.
  • Journal Title: Neuropathology Volume: N/A Pages: N/A
  • DOI: 10.1111/neup.12095
  • Peer Reviewed
• [Journal Article] Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice. (2013)
  • Author(s): suji, H., Ishii-Ohba, H., Shiomi, T., Shiomi, N., Katsube, T., Mori, M., Nenoi, M., Ohno, M., Yoshimura, D., Oka, S., Nakabeppu, Y., Tatsumi, K., Muto, M., and Sado, T.
  • Journal Title: J Radiat Res Volume: 54 Pages: 453-466
  • DOI: 10.1093/jrr/rrs128
  • Peer Reviewed
• [Journal Article] Neuroendocrine phenotypes in a boy with 5q14 deletion syndrome implicate the regulatory roles of myocyte-specific enhancer factor 2C in the postnatal hypothalamus. (2013)
  • Author(s): Sakai, Y., Ohkubo, K., Matsushita, Y., Akamine, S., Ishizaki, Y., Torisu, H., Ihara, K., Sanefuji, M., Kim, M.S., Lee, K.U., Shaw, C.A., Lim, J., Nakabeppu, Y., and Hara, T.
  • Journal Title: Eur J Med Genet Volume: 59 Pages: 475-783
  • DOI: 10.1016/j.ejmg.2013.06.009
  • Peer Reviewed
• [Journal Article] Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice. (2013)
  • Author(s): Matsumoto, A., Yamafuji, M., Tachibana, T., Nakabeppu, Y., Noda, M., and Nakaya, H.
  • Journal Title: Sci Rep Volume: 3 Pages: 3273
  • DOI: 10.1038/srep03273
  • Peer Reviewed
• [Journal Article] 核酸の酸化損傷に起因する神経変性の分子機序 (2013)
  • Author(s): 中別府雄作
  • Journal Title: 医学のあゆみ Volume: 24 Pages: 961-968
• [Presentation] Oxidation of nucleic acids and control mechanisms of genetic diversity in mammals. (2014)
  • Author(s): Yusaku Nakabeppu, Mizuki Ohno, Ryutaro Fukumura, Yuki Iwasaki, Yoshimichi Ikemura, Teruhisa Tsuzuki, Yoichi Gondo, Kunihiko Sakumi
  • Organizer: International Symposium on Germline Mutagenesis and Biodiversification
  • Place of Presentation: 福岡
  • Year and Date: 20140321-20140322
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• [Presentation] Drinking “hydrogen water” induces ghrelin secretion and protects dopaminergic neurons in MPTP-induced Parkinson’s disease model mice. (2014)
  • Author(s): Megumi Yamafuji, Akio Matsumoto, Tomoko Tachibana, Yusaku Nakabeppu, Mami Noda, Haruyuki Nakaya
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
  • Year and Date: 20140319-20140321
• [Presentation] 8-oxo-dGTP generated in nucleotide pools is a major cause of neurodegeneration under oxidative stress. (2014)
  • Author(s): Sheng Zijing, Sugako Oka, Yasuhiro Ikeda, Margherita Bignami, Yusaku Nakabeppu
  • Organizer: International symposium "New Frontier of Molecular Neuropathology 2014"
  • Place of Presentation: 東京
  • Year and Date: 20140316-20140317
• [Presentation] 8-Oxoguanine causes spontaneous de novo germline mutations : a study from the mutator mouse line. (2014)
  • Author(s): Mizuki Ohno, Kunihiko Sakumi, Ryutaro Fukumura, Yuki Iwasaki, Yoshimichi Ikemura, Teruhisa Tsuzuki, Yoichi Gondo, Yusaku Nakabeppu
  • Organizer: SMBE Satellite Meeting/NIG International Symposium: The Causes of Genome Evolution
  • Place of Presentation: 三島
  • Year and Date: 20140314-20140317
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• [Presentation] アルツハイマー病脳における糖尿病関連遺伝子の発現異常：久山町研究 (2013)
  • Author(s): 外間政朗，岡素雅子，Julio Leon，二宮利治，本田裕之，佐々木健介，岩城徹，小原知之，清原裕，中別府雄作
  • Organizer: 第18回日本神経精神医学会
  • Place of Presentation: 大阪
  • Year and Date: 20131213-20131214
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• [Presentation] Fosb遺伝子産物は補体C5aレセプターの遺伝子発現を制御することにより，ミクログリアの活性化に寄与している． (2013)
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  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 20131203-20131206
• [Presentation] 酸化DNA損傷と消化管がん． (2013)
  • Author(s): 大野みずき, 中津可道, 中別府雄作, 續輝久
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 20131203-20131206
• [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer's disease model mice. (2013)
  • Author(s): 岡素雅子, Julio Leon, 外間政朗, 加藤木敦央, 作見邦彦, 井手友美, Kang Dongchon, 中別府雄作
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 20131203-20131206
• [Presentation] デオキシイノシン三リン酸の蓄積はミスマッチ修復機構に依存した細胞増殖抑制とゲノム不安定性を引き起こす. (2013)
  • Author(s): 米嶋康臣, 土本大介, 外間政朗, Abolhassani Nona, 猪山輝昭, 作見邦彦, 塩見尚子, 森 雅彦, 塩見忠博, 中別府雄作
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 20131203-20131206
• [Presentation] Cytotoxic effects of X-ray irradiation on proliferating and differentiated human neuroblastoma cell line SH-SY5Y, and their modulation by BDNF and inhibitors for CDK5 and calpains. (2013)
  • Author(s): Erika Castillo, Julio Leon, 秋本頼子, 作見邦彦, 岡素雅子, 土本大介, 中別府雄作
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 20131203-20131206
• [Presentation] Fosb gene products regulate expression of C5ar1 and C5l2 genes and microglial activation. (2013)
  • Author(s): Hiroko Nomaru, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
  • Organizer: The 43rd annual meeting of the Society for neuroscience
  • Place of Presentation: San Diego. CA, USA.
  • Year and Date: 20131109-20131113
• [Presentation] Dual effects of Galectin-1 in amyotrophic lateral screlosis. (2013)
  • Author(s): Yuko Kobayakawa, Kunihiko Sakumi, yusaku Nakabeppu
  • Organizer: The 43rd annual meeting of the Society for neuroscience
  • Place of Presentation: San Diego. CA, USA.
  • Year and Date: 20131109-20131113
• [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice. (2013)
  • Author(s): Sugako Oka, Julio Leon, Masaaki Hokama, Atsuhisa Katogi, Sakumi Kunihiko, Dongchon Kang, Yusaku Nakabeppu
  • Organizer: International Symposium on Mitochondria 2013
  • Place of Presentation: 東京
  • Year and Date: 20131106-20131107
• [Presentation] MUTYH-dependent neurodegeneration initiated by mitochondrial accumulation of 8-oxoguanine in neurons is efficiently suppressed by MTH1 and OGG1 (2013)
  • Author(s): Zijing Sheng, Sugako Oka, Yusaku Nakabeppu
  • Organizer: 10th Conference of the Asian Society of Mitochondrial Research and Medicine (ASMRM)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20131104-20131105
  • Invited
• [Presentation] Oxidative stress-induced tumorigenesis in the small intestine of Mutyh-deficient mice: the effect of low-level exposure (2013)
  • Author(s): 續輝久, 大野みずき, 中津可道, 中別府雄作
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20131003-20131005
• [Presentation] MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via caspase-independent cell death pathway (2013)
  • Author(s): 岡素雅子, 中別府雄作
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20131003-20131005
• [Presentation] 活性酸素による核酸の酸化と哺乳動物における遺伝子多様性の制御機構 (2013)
  • Author(s): 中別府雄作, 大野みずき, 作見邦彦
  • Organizer: 日本遺伝学会第85回大会
  • Place of Presentation: 横浜
  • Year and Date: 20130919-20130921
• [Presentation] 酸化DNA 損傷に起因するde novo germline mutationの解析 (2013)
  • Author(s): 大野みずき, 作見邦彦, 福村龍太郎, 権藤洋一, 岩崎裕貴, 池村淑道, 續輝久, 中別府 雄作
  • Organizer: 日本遺伝学会第85回大会
  • Place of Presentation: 横浜
  • Year and Date: 20130919-20130921
• [Presentation] 酸化DNA 損傷に起因するde novo germline mutationの解析 (II) (2013)
  • Author(s): 作見邦彦, 大野みずき, 福村龍太郎, 権藤洋一, 岩崎裕貴, 池村淑道, 續輝久, 中別府 雄作
  • Organizer: 日本遺伝学会第85回大会
  • Place of Presentation: 横浜
  • Year and Date: 20130919-20130921
• [Presentation] Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study. (2013)
  • Author(s): 中別府雄作, 外間政朗, 岡素雅子, Julio Leon, 二宮利治, 本田裕之, 佐々木健介, 岩城徹, 小原知之, Frank M. LaFerla, 清原裕
  • Organizer: 包括的脳科学研究推進支援ネットワーク 平成25年度夏のワークショップ
  • Place of Presentation: 名古屋
  • Year and Date: 20130828-20130901
• [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice (2013)
  • Author(s): Sugako Oka, Dongchon Kang, Yusaku Nakabeppu
  • Organizer: Alzheimer's Association International Conference
  • Place of Presentation: Boston, MA, USA
  • Year and Date: 20130713-20130718
• [Presentation] Quantitative detection of oxidative DNA damage in brains of the triple transgenic Alzheimer’s disease mouse model (2013)
  • Author(s): Yoriko Akimoto, Sugako Oka, Julio Leon, Yusaku Nakabeppu
  • Organizer: Alzheimer's Association International Conference
  • Place of Presentation: Boston, MA, USA
  • Year and Date: 20130713-20130718
• [Presentation] 核酸損傷と生体防御 (2013)
  • Author(s): 中別府雄作, 岡素雅子, 盛子敬, 土本大介, 作見邦彦
  • Organizer: 第24回日本生体防御学会学術集会
  • Place of Presentation: 熊本
  • Year and Date: 20130710-20130712
  • Invited
• [Presentation] 活性分子種による核酸の化学修飾に起因する病態とその防御機構 (2013)
  • Author(s): 中別府雄作
  • Organizer: 老化促進モデルマウス(SAM)研究協議会 第28回研究発表会
  • Place of Presentation: 名古屋
  • Year and Date: 20130705-20130706
  • Invited
• [Presentation] Comprehensive analysis of gene expression regulated by Fosb gene in brain-derived cells (2013)
  • Author(s): Hiroko Nomaru, Kunihiko Sakumi, Noriko Yutsudo, Daisuke Tsuchimoto, Yusaku Nakabeppu
  • Organizer: Neuro2013 Joint Conference
  • Place of Presentation: 名古屋
  • Year and Date: 20130620-20130623
• [Presentation] Dual effects of Galectin-1 in amyotrophic lateral sclerosis (2013)
  • Author(s): Yuko Kobayakawa, Kunihiko Sakumi, Yusaku Nakabeppu
  • Organizer: Neuro2013 Joint Conference
  • Place of Presentation: 名古屋
  • Year and Date: 20130620-20130623
• [Presentation] Expression of the defense enzymes MTH1, OGG1 and MUTYH against oxidative damage in nucleic acids in the mouse brain (2013)
  • Author(s): Zijing Sheng, Yusaku Nakabeppu
  • Organizer: Neuro2013 Joint Conference
  • Place of Presentation: 名古屋
  • Year and Date: 20130620-20130623
• [Presentation] Quantitative detection of oxidative DNA damage in brains of the triple transgenic Alzheimer's disease mouse model. (2013)
  • Author(s): Yoriko Akimoto, Sugako Oka, Yusaku Nakabeppu
  • Organizer: Neuro2013 Joint Conference
  • Place of Presentation: 名古屋
  • Year and Date: 20130620-20130623
• [Presentation] fosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior (2013)
  • Author(s): 33. Noriko Yutsudo, Takashi Kamada, Kosuke Kajitani, Hiroko Nomaru, Atsuhisa Katogi, Yoko H. Ohnishi, Yoshinori N. Ohnishi, Kei-ichiro Takase, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
  • Organizer: Neuro2013 Joint Conference
  • Place of Presentation: 名古屋
  • Year and Date: 20130620-20130623
• [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer's disease model mice (2013)
  • Author(s): Sugako Oka, Dongchon Kang, Yusaku Nakabeppu
  • Organizer: Neuro2013 Joint Conference
  • Place of Presentation: 名古屋
  • Year and Date: 20130620-20130623
• [Presentation] Molecular hydrogen protects against ischemic injury in optic nerves (2013)
  • Author(s): Megumi Yamafuji, Kyota Fujita, Margaret Hamner, Nozomi Akimoto, Mizuho A Kido, Yoshinori Tanaka, Yusaku Nakabeppu, Bruce Ransom, Mami Noda
  • Organizer: Neuro2013 Joint Conference
  • Place of Presentation: 名古屋
  • Year and Date: 20130620-20130623
• [Presentation] Neuroprotection and slow aging induced by oxidative stress-resistant signaling driven by medical gas (2013)
  • Author(s): Mami Noda, Kyota Fujita, Margaret Hamner, Chieri Higashi, Megumi Yamafuji, Nozomi Akimoto, Mizuho A Kido, Yoshinori Tanaka, Yusaku Nakabeppu, Bruce Ransom
  • Organizer: Neuro2013 Joint Conference
  • Place of Presentation: 名古屋
  • Year and Date: 20130620-20130623
• [Presentation] 8-Oxoguanine in brain causes complex neurodegeneration through DNA repair (2013)
  • Author(s): 38. Zing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
  • Organizer: Gordon research conference on Oxidative Stress & Disease
  • Place of Presentation: Les Diablerets, Switzerland
  • Year and Date: 20130414-20130419
• [Presentation] Oxidation of nucleic acids by reactive oxygen species and control mechanisms of genetic diversity in mammals.
  • Author(s): Yusaku Nakabeppu, Mizuki Ohno, Kunihiko Sakumi
  • Organizer: International Symposium between Kyushu University Post-Global Centers of Excellence Program and School of Biomedical Sciences, Monash University
  • Place of Presentation: Melbourne, Australia
  • Invited
• [Presentation] Accumulation of deoxyinosine triphosphate induces mismatch repair-dependent cell growth arrest and instability of genomic DNA.
  • Author(s): Yasuto Yoneshima, Daisuke Tsuchimoto, Nona Abolhassani, Teruaki Iyama, Kunihiko Sakumi, Naoko Shiomi, Masahiko Mori, Tadahiro Shiomi, Yusaku Nakabeppu
  • Organizer: International Symposium between Kyushu University Post-Global Centers of Excellence Program and School of Biomedical Sciences, Monash University
  • Place of Presentation: Melbourne, Australia
• [Presentation] Microglial activation by Fosb gene.
  • Author(s): Hiroko Nomaru, Kunihiko Sakumi, Atsuhisa Katogi, Yoshinori N Ohnishisi, Daisuke Tsuchimoto, Yusaku Nakabeppu
  • Organizer: International Symposium between Kyushu University Post-Global Centers of Excellence Program and School of Biomedical Sciences, Monash University
  • Place of Presentation: Melbourne, Australia
• [Presentation] Quality Control of Nucleotide Pools is Essential for Cellular Homeostasis
  • Author(s): Yusaku Nakabeppu
  • Organizer: Invited seminar at Institute of Molecular Cancer Research University of Zurich
  • Place of Presentation: Zurich, Switzerland.
  • Invited
• [Book] Ganglion Cells: Morphology, Functional Development and Role in Disease (2014)
  • Author(s): Sango, K., Niimi, N., Tsukamoto, M., Utsunomiya, K., Sakumi, K., Nakabeppu, Y., Kadoya, T., and Horie, H.
  • Total Pages: 139
  • Publisher: Nova Science Publishers, Inc.
• [Book] 遺伝子変異の機構 (2014)
  • Author(s): 中別府雄作
  • Total Pages: N/A
  • Publisher: 中外医学社
• [Remarks] 九州大学生体防御医学研究所 個体機能制御学部門 脳機能制御学分野ホームページ
  • URL: http://www.bioreg.kyushu-u.ac.jp/nfg/index.html
• [Remarks] 九州大学生体防御医学研究所 個体機能制御学部門 脳機能制御学分野 概要
  • URL: http://www.bioreg.kyushu-u.ac.jp/mib/divisions/summary_ibn_ng.pdf
• [Remarks] 九州大学 研究者情報
  • URL: http://hyoka.ofc.kyushu-u.ac.jp/search/details/K000856/research.html