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2015 Fiscal Year Final Research Report

Analysis of host cellular transcriptional network induced by mononegavirus infection.

Research Project

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Project/Area Number 22228005
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionThe University of Tokyo

Principal Investigator

KAI CHIEKO  東京大学, 医科学研究所, 教授 (10167330)

Co-Investigator(Kenkyū-buntansha) YONEDA MISAKO  東京大学, 医科学研究所, 准教授 (40361620)
SATO HIROKI  東京大学, 医科学研究所, 助教 (50418654)
Co-Investigator(Renkei-kenkyūsha) HAYASHIZAKI YOSHIHIDE  独立行政法人理化学研究所, オミックス基盤研究領域, 領域長 (70192705)
Project Period (FY) 2010-04-01 – 2016-03-31
Keywordsモノネガウイルス / モービリウイルス / 転写制御 / CAGE / 病原性 / 持続感染
Outline of Final Research Achievements

In this work, we revealed transcriptional regulatory network induced by infection of morbilliviruses using a novel technique and bioinformatics analysis. As to highly pathogenic morbilliviruses and Nipah virus, which belong to the order mononegavirus, we analyzed the interaction between viral and cellular proteins and their post-translational modifications after infection, and revealed consequent influence on the virus life cycle and pathogenicity. In addition, we generated Tg mice expressing virus N protein as a model of persistent infection, and clarified a series of expression mechanisms of the unique pathogenicity.

Free Research Field

農学

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Published: 2017-05-10  

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