Integrative approaches toward the development of next-generation therapeutics for myocardial infarction

2015 Fiscal Year Final Research Report

• Project/Area Number: 22229007
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Advanced Telecommunications Research Institute International (2014-2015); Nara Institute of Science and Technology (2010-2013)
• Principal Investigator: Thomas N. Sato 株式会社国際電気通信基礎技術研究所, 佐藤匠徳特別研究所, 所長 (60548759)
• Co-Investigator(Kenkyū-buntansha): AKANUMA Takashi 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (50450721)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Keywords: 分子心臓病態学

Outline of Final Research Achievements

1.Identification of a family of angiocrine factors that are essential for organ regeneration. 2.Identification of a new class of inter-organ vascular network.
3.Identification of a drug that inhibits fibroblast-specific intracellular metabolism. We show that inhibition of fibrosis combined with increased cardiac angiogenesis caused by this drug improve cardiac function in myocardial infarction. 4.Identification of a new role of neurons in angiogenesis. 5.Identification of a family of cardiac factors that play critical roles in dysfunction of non-cardiac organs/tissues in cardiac diseases.

Free Research Field

医歯薬学