2015 Fiscal Year Final Research Report
The Epigenomic Analysis of Obesity and Insulin Resistance
Project/Area Number |
22229009
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Research Category |
Grant-in-Aid for Scientific Research (S)
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Allocation Type | Single-year Grants |
Research Field |
Metabolomics
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Research Institution | The University of Tokyo |
Principal Investigator |
SAKAI Juro 東京大学, 先端科学技術研究センター, 教授 (80323020)
|
Co-Investigator(Kenkyū-buntansha) |
KAWAMURA Takeshi 東京大学, アイソトープ総合センター, 准教授 (70306835)
|
Co-Investigator(Renkei-kenkyūsha) |
ABURATANI Hiroyuki 東京大学, 先端科学技術研究センター, 教授 (10202657)
SHINKAI Yoichi 理化学研究所, 眞貝細胞記憶研究室, 主任研究員 (20211972)
SAKURAI Takeshi 金沢大学, 医学系, 教授 (60251055)
|
Project Period (FY) |
2010-04-01 – 2016-03-31
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Keywords | メタボリックシンドローム / エピゲノム / ヒストン修飾酵素 / 脂肪細胞分化 |
Outline of Final Research Achievements |
Together with genetic predisposition for the development of life style-related diseases, environmental factors are greatly involved. Stimuli from the environment are responded through changes in the epigenome (i.e. DNA methylation and histone modifications) and chromatin 3D structure. We, from research in the fat cells, discovered a new “bivalent chromatin structure” that epigenome modifying enzyme forms to poise precursor fat cells undifferentiated. We also discovered that the initial response to environmental change such as cold was phosphorylation of epigenome modifying enzyme and the following protein complex formation plays a key role in response to cold for the regulate thermogenic gene transcription.
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Free Research Field |
内分泌代謝学
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