2013 Fiscal Year Final Research Report
in vivo Observation of Synapse Remodeling
| Project/Area Number |
22240042
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurophysiology and muscle physiology
|
|---|
| Research Institution | National Institute for Physiological Sciences |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUMIMOTO Hideki 九州大学, 医学研究院, 教授 (30179303)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
WATANABE Miho 浜松医科大学, 医学部, 助教 (10399321)
ETO Kei 生理学研究所, 発達生理学研究系, 特別協力研究員 (30545257)
KIM Sunkwang KyougHee大学, 韓国
|
|---|
| Project Period (FY) |
2010-04-01 – 2013-03-31
|
| Keywords | シナプス / 再編 / ２光子励起顕微鏡 / 生体観察 / グリア |
|---|
| Research Abstract |
We attempted to elucidate the synapse remodeling and its underlying mechanisms, e.g glial contribution, mainly by using in vivo multiphoton microscopy.1)glutamate could be an attractant only to activated microglia, 2) microglia could rescue the damaged neurons by direct contact onto the damaged site. 3) in developing cortex, microglia contribute to the generation of synapses. In addition, in the mature cortex, there are two subclasses of synapses, stable synapses with a larger head size, and unstable synapses with a smaller size in head. In case of pathological condition, such as chronic pain model, unstable synapse were preferentially eliminated and new spines were replaced with such a preexisting unstable synapses.
|
