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2013 Fiscal Year Final Research Report

Comprehensive study on optimum flow condition of total artificial heart from the view point of microcirculation

Research Project

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Project/Area Number 22240054
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionThe University of Tokyo

Principal Investigator

KOU Imachi  東京大学, 医学(系)研究科(研究院), 名誉教授 (10010076)

Co-Investigator(Renkei-kenkyūsha) ABE Yusuke  東京大学, 大学院・医学系研究科, 准教授 (90193010)
ISOYAMA Takashi  東京大学, 大学院・医学系研究科, 講師 (20302789)
SAITO Itsuro  東京大学, 大学院・医学系研究科, 特任研究員 (80334225)
Research Collaborator VASKU Jaromir  チェコマサリク大学, 医学部, 名誉教授
DOBSAK Petr  チェコマサリク大学, 医学部, 教授
ONO Toshiya  東京大学, 大学院・医学系研究科, 技術専門職員
INOUE Yusuke  東京大学, 大学院・工学系研究科, 特任研究員 (80611079)
Project Period (FY) 2010-04-01 – 2014-03-31
Keywords血行動態 / 微小循環 / 人工心臓 / 顕微鏡
Research Abstract

It was succeeded to develop the following research tools to clarify the influences of flow dynamic states of total artificial heart such as pulsatile flow, continuous flow, etc. on microcirculation of the living body; 1) Undulation pump total artificial heart that was enough compact to be implanted into the chest cavity of a goat weighing 40 Kg and could generate any style of flow waveform, was developed. 2) A microcirculation probe that could be implanted into the body and observe continuously the microcirculation in the peripheral system without a microscope was developed. 3) These systems were implanted into goats chronically. The longest implantation period was half yeart and the difference between pulsatile and continuous flow on the living body including microcirculation was analysed during this period.

  • Research Products

    (23 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (15 results) (of which Peer Reviewed: 13 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] Computational fluid dynamics analysis of the pump parameters in the helical flow pump2014

    • Author(s)
      Hosoda K, Ishii K, Isoyama T, Saito I, Inoue Y, Ariyoshi K, Ono T, Nakagawa H, Imachi K, Kumagai H, Abe Y
    • Journal Title

      J Artif Organs

      Volume: 17 Pages: 9-15

    • DOI

      10.1007/s10047-013-0739-8

    • Peer Reviewed
  • [Journal Article] The helical flow total artificial heart : implantation in goats2013

    • Author(s)
      Abe Y, Ishii K, Isoyama T, Saito I, Inoue Y, Sato M, Hara S, Hosoda K, Ariyoshi K, Nakagawa H, Ono T, Fukazawa K, Ishihara K, Imachi K
    • Journal Title

      Proc 35th Ann Intern Conf IEEE EMBS

      Pages: 2720-3

    • Peer Reviewed
  • [Journal Article] Emergency Life Support System aiming preprimed oxygenator2013

    • Author(s)
      Isoyama T, Ariyoshi K, Nii K, Saito I, Fukunaga K, Inoue Y, Ono T, Ishii K, Hara S, Imachi K, Takai M, Abe Y
    • Journal Title

      Proc 35th Ann Intern Conf IEEE EMBS

      Pages: 5731-4

    • Peer Reviewed
  • [Journal Article] Pulsatile Driving of the Helical Flow Pump2013

    • Author(s)
      Ishii K, Hosoda K, Isoyama T, Saito I, Ariyoshi K, Inoue Y, Sato M, Hara S, lee X, Wu S, Ono T, Nakagawa H, Imachi K, Abe Y
    • Journal Title

      Proc 35th Ann Intern Conf IEEE EMBS

      Pages: 2724-7

    • Peer Reviewed
  • [Journal Article] Relation between Left Atrial Pressure and the Corresponding Pulse Pressure in the Helical Flow Total Artificial Heart2013

    • Author(s)
      Wu S-Y, Saito I, Isoyama T, Inoue Y, Ishii K, Sato M, Hara S, Hosoda K, Ariyoshi K, Li X, Nakagawa H, Ono T, Abe Y
    • Journal Title

      Proc 35th Ann Intern Conf IEEE EMBS

      Pages: 671-4

    • Peer Reviewed
  • [Journal Article] A New Control Method Depending on Primary Phase Angle of Transcutaneous Energy Transmission System for Artificial heart2013

    • Author(s)
      H. Miura, I. Saito, F. Sato, Y. Shiraishi, T. Yambe, and H. Matsuki
    • Journal Title

      Proc 35th Ann Intern Conf IEEE EMBS

      Pages: 5723-6

    • Peer Reviewed
  • [Journal Article] Characteristics of magnetic probes for identifying sentinel lymph nodes2013

    • Author(s)
      Tetsu Ookubo, Yusuke Inoue, Dongmin Kim, Hiroyuki Ohsaki, Yusuke Mashiko, Moriaki Kusakabe, and Masaki Sekino
    • Journal Title

      Proc 35th Ann Intern Conf IEEE EMBS

      Pages: 5485-8

    • Peer Reviewed
  • [Journal Article] Development of Normal-Suction Boundary Control Method Based on Inflow Cannula Pressure Waveform for the Undulation Pump Ventricular Assist Device2012

    • Author(s)
      Kohei Ishii, Itsuro Saito, Takashi Isoyama, Hidemoto Nakagawa, Nakano Emiko, Toshiya Ono, Wei Shi, Yusuke Inoue, and Yusuke Abe
    • Journal Title

      Artificial Organs

      Volume: 36(9) Pages: 812-816

    • DOI

      10.1111/j.1525-1594.2012.01451.x

    • Peer Reviewed
  • [Journal Article] The helical flow pump with a hydrodynamic levitation impeller2012

    • Author(s)
      Abe Y, Ishii K, Isoyama T, Saito I, Inoue Y, Ono T, Nakagawa H, Nakano E, Fukazawa K, Ishihara K, Fukunaga K, Ono M, Imachi K
    • Journal Title

      J Artif Organs

      Volume: 15 Pages: 331-340

    • DOI

      10.1007/s10047-012-0659-z

    • Peer Reviewed
  • [Journal Article] Real-time in-home patient monitoring systems using high-speed mobile Internet and remote access2012

    • Author(s)
      T. Isoyama, H. Yamada, I. Saito, M. Sato, Y. Okada, K. Miyahara, H. Ohta, and Y. Abe
    • Journal Title

      Proceeding of International Conference on uHealthcare 2012

      Pages: 25-26

  • [Journal Article] Development of an Implantable Small Observation Camera with Scaffold Chamber for Angiogenesis2012

    • Author(s)
      Yusuke Inoue, Itsuro Saito, Takashi Isoyama, Hidemoto Nakagawa, Toshiya Ono, Kohei Ishii, Koki Ariyoshi, Emiko Nakano, Kou Imachi, Yusuke Abe
    • Journal Title

      World Congress 2012 Medical Physics and Biomedical Engineering Proceedings

      Volume: 39 Pages: 1961-1964

  • [Journal Article] Automatic calibration of the inlet pressure sensor for the implantable continuous-flow ventricular assist device2011

    • Author(s)
      Wei Shi, Itsuro Saito, Takashi Isoyama, Hidemoto Nakagawa, Yusuke Inoue, Toshiya Ono, Akimasa Kouno, Kou Imachi, Yusuke Abe
    • Journal Title

      Journal of Artificial Organs

      Volume: 14 Pages: 81-88

    • DOI

      10.1007/s10047-011-0556-x

    • Peer Reviewed
  • [Journal Article] Results of animal experiments with the fourth model of the undulation pump total artificial heart in goat2011

    • Author(s)
      Abe Y, Isoyama T, Saito I, Shi W, Inoue Y, Ishii K, Nakagawa H, Ono T, Ono M, Imachi K
    • Journal Title

      Artificial Organs

      Volume: 35(8) Pages: 781-790

    • DOI

      10.1111/j.1525-1594.2011.01318.x

    • Peer Reviewed
  • [Journal Article] Preliminary study of physiological control for the undulation pump ventricular assist device2010

    • Author(s)
      Saito I, Ishii K, Isoyama T, Ono T, Nakagawa H, Shi W, Inoue Y, Abe Y
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc

      Volume: 2010 Pages: 5218-21

    • Peer Reviewed
  • [Journal Article] Use of In Vivo Insert Molding to Form a Jellyfish Valve Leaflet2010

    • Author(s)
      Kishi A, Isoyama T, Saito I, Miura H, Nakagawa H, Kouno A, Ono T, Inoue Y, Yamaguchi S, Wei S, Abe Y, Imachi K, and Noshiro M
    • Journal Title

      Artificial Organs

      Volume: 34(12) Pages: 1125-1131

    • Peer Reviewed
  • [Presentation] Total artificial heart : what we need?2013

    • Author(s)
      Yusuke Abe
    • Organizer
      JSAO & IFAO Joint Congress 2013
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Japan
    • Year and Date
      2013-09-29
  • [Presentation] Development of a physiological control method for the helical flow total artificial heart2013

    • Author(s)
      Itsuro Saito, Takashi Isoyama, Yusuke Inoue, Masami Sato, Shintaro Hara, Li Xin Yang, Terumi Yurimoto, Haruka Murakami, Wu Sheng Yuan, Yukino Kawase, Yusuke Abe
    • Organizer
      JSAO & IFAO Joint Congress 2013
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Japan
    • Year and Date
      2013-09-28
  • [Presentation] Flow rate and pressure head estimation in helical flow pump using the table method2013

    • Author(s)
      Shintaro Hara, Itsuro Saito, Xinyang Li, Takashi Isoyama, Yusuke Inoue, Kohei Ishii, Masami Sato, Sheng Yuan Wu, Koki Ariyoshi, Yukino Kawase, Yoshinori Kusakabe, Terumi Yurimoto, Haruka Murakami and Yusuke Abe
    • Organizer
      JSAO & IFAO Joint Congress 2013
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Japan
    • Year and Date
      2013-09-28
  • [Presentation] The nonlinearity of left atrium volume-pressure relationship and the applicability in the pressure sensor calibration of helical flow total artificial heart (HFTAH)2013

    • Author(s)
      Sheng-Yuan Wu, Itsuro Saito, Takashi Isoyama, Yusuke Inoue, Masami Sato, Shintaro Hara, Xinyang Li, Terumi Yurimoto, Haruka Murakami, Yukino Kawase, Yusuke Abe
    • Organizer
      JSAO & IFAO Joint Congress 2013
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Japan
    • Year and Date
      2013-09-28
  • [Presentation] Troidal Convolution blood Pump for ECLS system2013

    • Author(s)
      Takashi Isoyama, Koki Ariyoshi, Itsuro Saito, Kazuyoshi Fukunaga, Kou Imachi, and Yusuke Abe
    • Organizer
      ASAIO 2013
    • Place of Presentation
      Chicago Hilton, Illinois, USA
    • Year and Date
      2013-06-13
  • [Presentation] DEVELOPMENT OF HYBRID INFLOW CANNULA FOR VENTRICULAR ASSIST DEVICES2012

    • Author(s)
      Yusuke Inoue, Emiko Nakano, Itsuro Saito, Takashi Isoyama, Hidemoto Nakagawa, Toshiya Ono, Kohei Ishii, Koki Ariyoshi, Kou Imachi, Yusuke Abe
    • Organizer
      39th Congress of ESAO
    • Place of Presentation
      Academy of Music and Theatre, Rostock, Germany
    • Year and Date
      2012-09-28
  • [Presentation] Development of Hybrid Inflow Cannula for Helical Flow Ventricular Assist Device2012

    • Author(s)
      Yusuke Inoue, Emiko Nakano, Itsuro Saito, Takashi Isoyama, Hidemoto Nakagawa, Toshiya Ono, Kohei Ishii, Koki Ariyoshi, Kou Imachi, Yusuke Abe
    • Organizer
      ISRBP2012 (20th Congress of the International Society for Rotary Blood Pumps)
    • Place of Presentation
      Grand Cevahir Hotel, Istanbul, Turkey
    • Year and Date
      2012-09-21
  • [Remarks]

    • URL

      http://www.bme.gr.jp

URL: 

Published: 2015-06-25  

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