2013 Fiscal Year Final Research Report
Intercellular signaling network for the remodeling of skeletal muscle tissue in response to various extracellular stimuli -Application for sports sciences-
| Project/Area Number |
22240071
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Hirosaki Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
GOTO Katsumasa 豊橋創造大学, 保健医療学部, 教授 (70239961)
KATAGIRI Nobuko 弘前学院大学, 看護学部, 講師 (30075428)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 骨格筋可塑性 / マイクロRNA / follistatin / TRIM72 / angiopoietin 1 / adiponectin / 細胞間コミュニケーション / シグナル伝達 |
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| Research Abstract |
The purpose of this study was to investigate the intracellular signaling networks for the remodeling of skeletal muscle tissue in response to various extracellular stimuli. Protein and mRNA expression levels of skeletal muscle-specific molecules, which paracrine to various cells, and skeletal muscle membrane-specific proteins were evaluated in skeletal muscle tissue as well as cultured muscle cells following various extracellular stimuli. Evidences suggest that skeletal muscle-derived molecules and the muscle membrane-specific proteins function as intercellular communicators between skeletal muscle cells and other cells in skeletal muscle tissue to regulate the size and the function of skeletal muscle.
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[Journal Article] AICAR-induced activation of AMPK negatively regulates myotube hypertrophy through HSP72-mediated pathway in C2C12 skeletal muscle cells2014
Author(s)
Egawa, T., Ohno, Y., Goto, A., Ikuta, A., Suzuki, M., Ohira, T., Yokoyama, S., Sugiura, T., Ohira, Y., Yoshioka, T., Goto, K
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Journal Title
Am. J. Physiol. Endocrinol. Metab
Volume: Vol.306, No.3
Pages: E344-E354
DOI
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[Journal Article] Effects of gravitational loading levels on protein expression related to metabolic and/or morphologic properties of mouse neck muscles2014
Author(s)
Ohira Tom, Ohira, Tak., Kawano, F., Shibaguchi, T., Okabe, H., Goto, K., Ogita, F., Sudoh, M., Roy, R.R., Edgerton, V.R., Cancedda, R., Ohira, Y
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Journal Title
Physiol. Rep
Volume: Vol.2, No.1
Pages: e00183
DOI
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[Journal Article] Up-regulation of adiponectin expression in antigravitational soleus muscle in response to unloading followed by reloading, and functional overloading in mice2013
Author(s)
Goto, A., Ohno, Y., Ikuita, A., Suzuki, M., Ohira, T., Egawa, T., Nakai, A., Sugiura, T., Yoshioka, T., Ohira, Y., Goto, K
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Journal Title
PLoS ONE
Volume: Vol.8, No.12
Pages: e81929
DOI
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[Journal Article] Heat shock transcription factor 1-deficiency attenuates overloading-associated hypertrophy of mouse soleus muscle2013
Author(s)
Koya, T., Nishizawa, S., Ohno, Y., Goto, A., Ikuita, A., Suzuki, M., Ohira, T., Egawa, T., Nakai, A., Sugiura, T., Ohira, Y., Yoshioka, T., Beppu, M., Goto, K
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Journal Title
PLoS ONE
Volume: Vol.8, No.10
Pages: e77788
DOI
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[Journal Article] Regeneration of injured skeletal muscle in heat shock transcription factor 1-null mice2013
Author(s)
Nishizawa, S., Koya, T., Ohno, Y., Goto, A., Ikuita, A., Suzuki, M., Ohira, T., Egawa, T., Nakai, A., Sugiura, T., Ohira, Y., Yoshioka, T., Beppu, M., Goto, K
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Journal Title
Physiol. Rep
Volume: Vol.1, No.3
Pages: e00071
DOI
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[Journal Article] Microcurrent electrical nerve stimulation facilitates regrowth of mouse soleus muscle2013
Author(s)
Ohno, Y., Fujiya, H., Goto, A., Nakamura, A., Nishiura, Y., Sugiura, T., Ohira, Y., Yoshioka, T., Goto, K
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Journal Title
Intl. J. Med. Sci
Volume: Vol.10, No.10
Pages: 1286-1294
DOI
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[Journal Article] Effects of heat stress on muscle mass and the expression levels of heat shock proteins and lysosomal cathepsin L in soleus muscle of young and aged mice2012
Author(s)
Ohno, Y., Yamada, S., Goto, A., Ikuta, A., Sugiura, T., Ohira, Y., Yoshioka, T., Goto, K
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Journal Title
Mol. Cell. Biochem
Volume: Vol.369, No.1-2
Pages: 45-53
DOI
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[Journal Article] Some aspects of heat stress on the plasticity of skeletal muscle cells2012
Author(s)
Goto, K., Ohno, Y., Goto, A., Ikuta, A., Suzuki, M., Ohira, T., Tsuchiya, N., Nishizawa, S., Koya, T., Egawa, T., Sugiura, T., Ohira, Y., Yoshioka, T
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Journal Title
J. Phys. Fit. Sports Med
Volume: Vol.1, No.2
Pages: 197-204
DOI
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[Journal Article] Absence of heat shock transcription factor 1 retards the regrowth of atrophied soleus muscle in mice2011
Author(s)
Yasuhara, K., Ohno, Y., Kojima, A., Uehara, K., Beppu, M., Sugiura, T., Fujimoto, M., Nakai, A., Ohira, Y., Yoshioka, T., Goto, K
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Journal Title
J. Appl. Physiol
Volume: Vol.111, No.4
Pages: 1142-1149
DOI
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[Journal Article] Possible role of NF-ĸB signals in heat-stress-associated increase in protein content of cultured C2C12 cells2011
Author(s)
Ohno, Y., Yamada, S., Sugiura, T., Ohira, Y., Yoshioka, T., Goto, K
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Journal Title
Cells Tissues Organs
Volume: Vol.194, No.5
Pages: 363-370
DOI
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[Journal Article] Responses of muscle mass, strength and gene transcripts to long-term heat stress in healthy human subjects2011
Author(s)
Goto, K., Oda, H., Kondo, H., Igaki, M., Suzuki, A., Tsuchiya, S., Murase, T., Hase, T., Fujiya, H., Matsumoto, I., Naito, H., Sugiura, T., Ohira, Y., Yoshioka, T
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Journal Title
Eur. J. Appl. Physiol
Volume: Vol.111, No.1
Pages: 17-27
DOI
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[Journal Article] A possible role of NF-ĸB and HSP72 in skeletal muscle hypertrophy induced by heat stress in rats2010
Author(s)
Ohno, Y., Yamada, S., Sugiura, T., Ohira, Y., Yoshioka, T., Goto, K
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Journal Title
Gen. Physiol. Biophys
Volume: Vol.29, No.3
Pages: 234-242
DOI
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