2012 Fiscal Year Final Research Report
Mechanism and regulation of gastric carcinogenesis directed by the Helicobacter pylori CagA oncoprotein
| Project/Area Number |
22240085
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Carcinogenesis
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 癌 / 感染症 / 細菌 / シグナル伝達 |
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| Research Abstract |
Helicobacter pylori CagA-positive strains play a key role in thedevelopment of gastric carcinoma. This project elucidated 1) the mechanism by which H. pylori delivers its oncoprotein CagA into host gastric epithelial cells: 2) identified Pragmin,a human protein the function of which is mimicked by delivered CagA: and 3) uncoveredmolecular pathway that directs reprograming of gastric epithelial cells into intestinal-likecells upon chronic infection with cagA-positive H. pylori. Finally, the H. pylori CagAprotein was crystalized and its three-dimensional structure was solved by X-ray analysis.
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[Journal Article] CDX1 directs gastric intestinalmetaplasia via induction of stemness-associatedreprogramming factors SALL4 and KLF5. Proc.Natl.2012
Author(s)
Fujii, Y., Yoshihashi, K., Tsutsumi, S., Mutoh,H., Suzuki, H., Maeda, S., Aburatani, H. andHatakeyama, M.
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Journal Title
Acad. Sci. USA
Volume: 109
Pages: 20584-20589
Peer Reviewed
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[Journal Article] Reactiveoxygen species-induced autophagic degradationof Helicobacter pylori CagA is specificallysuppressed in cancer stem-like cells.2012
Author(s)
Tsugawa, H., Suzuki, H., Saya, H.,Hatakeyama, M., Hirayama, T., Hirata, K.,Nagano, O., Matsuzaki, J. and Hibi, T.
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Journal Title
Cell HostMicrobe
Volume: 12
Pages: 764-777
Peer Reviewed
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[Journal Article] Tertiary structure-function analysis reveals thepathogenic signaling potentiation mechanism ofHelicobacter pylori oncogenic effector CagA.2012
Author(s)
Hayashi, T., Senda, M., Morohashi, H.,Higashi, H., Horio, M., Nagase, L., Sasaya, D.,Shimizu, T., Venugopalan, N., Kumeta, H., Noda,N. N., Inagaki, F., Senda, T. and Hatakeyama, M.
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Journal Title
Cell Host Microbe
Volume: 12
Pages: 20-33
Peer Reviewed
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[Journal Article] Giraud, A.S. and Menheniott,2012
Author(s)
Lee, K.S., Kalantzis, A., Jackson, C.B.,O'Connor, L., Mutaya-Kamiya, N., Hatakeyama,M., Judd, L.M.
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Journal Title
T.R. Plos One
Volume: 7
Pages: e30786
Peer Reviewed
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[Journal Article] Rozenblatt-Rosen, O., Meyerson, M., Neel, B. G.and Hatakeyama, M. SHP2 tyrosine phosphataseconverts parafibromin/Cdc73 from a tumorsuppressor to an oncogenic driver.2011
Author(s)
Takahashi, A., Tsutsumi, R., Kikuchi, I.,Obuse, C., Saito, Y., Seidi, A., Karisch, R.,Fernandez, M., Cho, T., Ohnishi, N.,
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Journal Title
Mol. Cell
Volume: 43
Pages: 45-56
Peer Reviewed
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[Journal Article] The CagA protein of Helicobacterpylori suppresses the functions of DCs in mice.2010
Author(s)
Tanaka, H., Yoshida, M., Nishiumi, S.,Ohnishi, N., Kobayashi, K., Yamamoto, K.,Fujita, T., Kutsumi, H., Hatakeyama, M. andAzuma, T.
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Journal Title
Arch. Biochem. Biophys
Volume: 7
Pages: 35-42
Peer Reviewed
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[Journal Article] Helicobacter pylori-induced histonemodification, associated gene expression ingastric epithelial cells, and its implication inpathogenesis.2010
Author(s)
Ding, S-Z., Fischer, W., Kaparakis-Liaskos,M., Lietchi, G., Merrell, S., Grant, P., Ferrero, R.,Crowe, S., Haas, R., Hatakeyama, M. andGoldberg, J.
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Journal Title
Plos One
Volume: 5
Pages: e9875
Peer Reviewed
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[Presentation] Oncogenic Mechanism of Helicobacter pylori CagA2011
Author(s)
畠山昌則
Organizer
The 21stHiroshima Cancer Seminar (HCS)/The 5thThree Universities? ConsortiumInternational Symposium "Recent Progressin Carcinogenesis, Progression andManagement of Upper GI Cancers.
Place of Presentation
International Conference CenterHiroshima, Hiroshima
Year and Date
2011-11-05
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