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2012 Fiscal Year Final Research Report

Large-scale cohort molecular epidemiological study after the Chernobyl accident

Research Project

  • PDF
Project/Area Number 22256004
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Endocrinology
Research InstitutionNagasaki University

Principal Investigator

YAMASHITA Shunichi  長崎大学, 医歯薬学総合研究科, 教授 (30200679)

Co-Investigator(Kenkyū-buntansha) TAKAMURA Noboru  長崎大学, 医歯薬学総合研究科, 教授 (30295068)
NAKASHIMA Masahiro  長崎大学, 医歯薬学総合研究科, 教授 (50284683)
MITSUTAKE Norisato  長崎大学, 医歯薬学総合研究科, 助教 (50404215)
SAENKO Vladimir  長崎大学, 医歯薬学総合研究科, 准教授 (30343346)
Project Period (FY) 2010 – 2012
Keywordsチェルノブイリ / 甲状腺がん / 分子疫学調査 / がん組織バンク / 放射線影響
Research Abstract

Taken together with our continuous support to the joint research in Belarus, we have newly established the target population in Ukraine. Our cohort is now the world-top class for molecular epidemiological analysis of post-Chernobyl thyroid cancer cases. Our data suggest that there are no association between the proximity of NKX2-1 SNP and radiation-associated thyroid cancers. In March 11 2011, the Great East Japan Earthquake occurred and then subsequently the Fukushima Nuclear Power Plant (NPP) accident happened. Therefore, we have immediately responded to Fukushima to apply our know-how on emergency radiation medicine and crisis/risk communication at the standpoint of “Radiation Exposure and Health Effects” on a basis of Chernobyl experience and our own international cooperative research network.

  • Research Products

    (61 results)

All 2013 2012 2011 2010 Other

All Journal Article (18 results) (of which Peer Reviewed: 17 results) Presentation (41 results) Remarks (2 results)

  • [Journal Article] Vertical Distribution and Estimated Doses from Artificial Radionuclides in Soil Samples around the Chernobyl Nuclear Power Plant and the Semipalatinsk Nuclear Testing Site2013

    • Author(s)
      Taira Y, Yamashita S, Takamura N, et al
    • Journal Title

      PLoS One

      Volume: 8(2) Pages: e57524

    • DOI

      doi:10.1371/journal.pone.0057524

    • Peer Reviewed
  • [Journal Article] Adverse effects of iodine thyroid blocking: a systematic review2012

    • Author(s)
      Spallek L, Krille L, Reiners C, Schneider R, Yamashita S, Zeeb H
    • Journal Title

      Radiat Prot Dosimetry

      Volume: 150(3) Pages: 267-277

    • DOI

      doi:10.1093/rpd/ncr400

    • Peer Reviewed
  • [Journal Article] Low-dose Radiation Exposure and Carcinogenesis2012

    • Author(s)
      Suzuki K, Yamashita S
    • Journal Title

      Jpn J Clin Oncol

      Volume: 42(7) Pages: 563-568

    • DOI

      doi:10.1093/jjco/hys078

    • Peer Reviewed
  • [Journal Article] Importance of personal dose equivalent evaluation in Fukushima in overcoming social panic.2012

    • Author(s)
      Yoshida K, Hashiguchi K, Taira Y, Matsuda N, Yamashita S, Takamura N
    • Journal Title

      Radiat Prot Dosimetry

      Volume: 151(1) Pages: 144-146

    • DOI

      doi:10.1093/rpd/ncr466

    • Peer Reviewed
  • [Journal Article] Study protocol for the fukushima health management survey2012

    • Author(s)
      Yasumura S, Hosoya M, Yamashita S, Kamiya K, Abe M, Akashi M, Kodama K, Ozasa K
    • Journal Title

      J Epidemiol

      Volume: 22(5) Pages: 375-383

    • DOI

      doi:10.2188/jea.JE20120105

    • Peer Reviewed
  • [Journal Article] Environmental contamination and external radiation dose rates from radionuclides released from the Fukushima Nuclear Power Plant2012

    • Author(s)
      Taira Y, Hayashida N, Yamashita S, Kudo T, Matsuda N, Takahashi J, Gutevitc A, Kazlovsky A, Takamura N
    • Journal Title

      Radiat Prot Dosimetry

      Volume: 151(3) Pages: 537-545

    • DOI

      doi:10.1093/rpd/ncs040

    • Peer Reviewed
  • [Journal Article] Evaluation of Environmental Contamination and Estimated Radiation Doses for the Return to Residents' Homes in Kawauchi Village, Fukushima Prefecture.2012

    • Author(s)
      Taira Y, Hayashida N, Yamaguchi H, Yamashita S, Endo Y, Takamura N
    • Journal Title

      PLoS One

      Volume: 7(9) Pages: e45816

    • DOI

      doi:10.1371/journal.pone.0045816

    • Peer Reviewed
  • [Journal Article] Survey of the WHO-REMPAN network's capability for strengthening preparedness for radiological and nuclear emergencies2012

    • Author(s)
      Kumagai A, Carr Z, Ohtsuru A, Christie D, Yamashita S
    • Journal Title

      Radiat Prot Dosimetry

      Volume: 151(4) Pages: 607-610

    • DOI

      doi:10.1093/rpd/ncs155

    • Peer Reviewed
  • [Journal Article] Prognosis of thyroid nodules in individuals living in the Zhitomir region of Ukraine2012

    • Author(s)
      Hayashida N, Yamashita S, Takamura N, et al
    • Journal Title

      PLos One

      Volume: 7(11) Pages: e50648

    • Peer Reviewed
  • [Journal Article] Current concentration of artificial radionuclides and estimated radiation doses from 137Cs around the Chernobyl Nuclear Power Plant, the Semipalatinsk Nuclear Testing Site, and in Nagasaki2011

    • Author(s)
      Taira Y, Hayashida N, Brahmanandhan GM, Nagayama Y, Yamashita S, Takahashi J, Gutevitc A, Kazlovsky A, Urazalin M, Takamura N
    • Journal Title

      J Radiat Res (Tokyo)

      Volume: 52(1) Pages: 88-95

    • DOI

      doi:10.1269/jrr.10104

    • Peer Reviewed
  • [Journal Article] Radiation exposure does not significantly contribute to the risk of recurrence of Chernobyl thyroid cancer.2011

    • Author(s)
      Rumyantsev PO, Saenko VA, Mitsutake N, Tsyb AF, Yamashita S. et al
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 96(2) Pages: 385-393

    • DOI

      doi:10.1210/jc.2010-1634

    • Peer Reviewed
  • [Journal Article] Thyroid cancer incidence in Ukraine: trends with reference to the Chernobyl accident2011

    • Author(s)
      Fuzik M, Saenko V, Yamashita S, et al
    • Journal Title

      Radiation Environ Biophys

      Volume: 50(1) Pages: 47-55

    • DOI

      doi:10.1007/s00411-010-0340-y

    • Peer Reviewed
  • [Journal Article] The Chernobyl accident and its consequences2011

    • Author(s)
      Saenko V, Yamashita S, et al
    • Journal Title

      Clin Oncol (R Coll Radiol)

      Volume: 23(4) Pages: 234-243

    • DOI

      doi:10.1016/j.clon.2011.01.502

    • Peer Reviewed
  • [Journal Article] The FOXE1 and NKX2-1 loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese population2011

    • Author(s)
      Matsuse M, Takahashi M, Mitsutake N, Saenko V, Bychkov A, Suzuki K, Matsuo K, Yamashita S, et al
    • Journal Title

      J Med Genet

      Volume: 48(9) Pages: 645-648

    • DOI

      doi:10.1136/jmedgenet-2011-100063

    • Peer Reviewed
  • [Journal Article] Screening for 137Cs body burden due to the Chernobyl accident in Korosten city, Zhitomir, Ukraine2011

    • Author(s)
      Hayashida N, Yamashita S, Takamura N, et al
    • Journal Title

      J Radiat Res (Tokyo)

      Volume: 52(5) Pages: 629-633

    • DOI

      doi:10.1269/jrr.11017

    • Peer Reviewed
  • [Journal Article] The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl2010

    • Author(s)
      Takahashi M, Saenko VA, Mitsutake N,Takamura N, Yamashita S, et al
    • Journal Title

      Hum Mol Genet

      Volume: 19(12) Pages: 2516-2523

    • DOI

      doi:10.1093/hmg/ddq123

    • Peer Reviewed
  • [Journal Article] Evaluation of 137CS body burden in inhabitants of Bryansk oblast, Russian Federation, where a high incidence of thyroid cancer was observed after the accident at the Chernobyl Nuclear Power Plant2010

    • Author(s)
      Sekitani Y, Hayashida N, Karevskaya IV, Vasilitsova OA, Kozlovsky A, Omiya M, Yamashita S, Takamura N
    • Journal Title

      Radiat Prot Dosimetry

      Volume: 141(1) Pages: 36-42

    • DOI

      doi:10.1093/rpd/ncq137

    • Peer Reviewed
  • [Journal Article] Chernobyl thyroid cancer 25 years after: in search of a molecular radiation signature2010

    • Author(s)
      Saenko V, Yamashita S
    • Journal Title

      Hot Thyroidology

      Volume: HT 8/10

    • URL

      https://www. Hotthyroidology.com

  • [Presentation] Radiation and thyroid cancer , Foundation for Promotion of Cancer Research2012

    • Author(s)
      Vladimir Saenko
    • Organizer
      The 25th International symposium
    • Place of Presentation
      東京
    • Year and Date
      20121206-08
  • [Presentation] ウクライナ成人の甲状腺乳頭癌の組織像は本邦症例と異なるのか?2012

    • Author(s)
      伊東正博、ボグダノワ タチアナ、サエンコ ウラジミール、前田茂人、近藤久義、中島正洋、山下俊一
    • Organizer
      第55回日本甲状腺学会
    • Place of Presentation
      福岡
    • Year and Date
      20121129-1201
  • [Presentation] Molecular epidemiology study of Chernobyl thyroid cancer in an extended sample set from Belarus and Ukraine2012

    • Author(s)
      サエンコ ウラジミール、光武範吏、高村昇、松田文彦、山下俊一, et al
    • Organizer
      第55回日本甲状腺学会
    • Place of Presentation
      福岡
    • Year and Date
      20121129-1201
  • [Presentation] Global Radiation Medicine: Educational Challenges for Academia2012

    • Author(s)
      Shunichi Yamashita
    • Organizer
      IAEA's organized Consultants' Meeting
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      20121029-1102
  • [Presentation] Nuclear Accidentand Thyroid Disease2012

    • Author(s)
      Shunichi Yamashita
    • Organizer
      10th Asia and Oceania Thyroid Association Congress
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      20121021-24
  • [Presentation] Radiation Induced Thyroid Carcinogenesis2012

    • Author(s)
      Vladimir Saenko
    • Organizer
      10th Asia and Oceania Thyroid Association Congress
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      20121021-24
  • [Presentation] 放射線災害医療:福島原発事故の教訓から2012

    • Author(s)
      山下俊一
    • Organizer
      第14回日本医療マネジメント学会学術総会
    • Place of Presentation
      佐世保
    • Year and Date
      20121012-13
  • [Presentation] 福島原発事故と放射線健康リスク管理2012

    • Author(s)
      山下俊一
    • Organizer
      第48回日本医学放射線学会秋季臨床大会
    • Place of Presentation
      長崎
    • Year and Date
      20120928-30
  • [Presentation] チェルノブイリの教訓から2012

    • Author(s)
      大津留晶、安村誠司、鈴木眞一、細弓光亮、藤森敬也、神谷研二、阿部正文、山下俊一
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      仙台
    • Year and Date
      20120906-08
  • [Presentation] チェルノブイリ組織バンクの現状と新たな展開2012

    • Author(s)
      伊東正博、中島正洋、山下俊一, et al
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      仙台
    • Year and Date
      20120906-08
  • [Presentation] 福島県川内村における帰村に向けた環境放射能レベルの把握と被ばくリスク評価2012

    • Author(s)
      平良文亨、林田直美、山下俊一、高村昇
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      仙台
    • Year and Date
      20120906-08
  • [Presentation] 放射線と甲状腺;チェルノブイリの教訓から福島原発事故を考える2012

    • Author(s)
      山下俊一
    • Organizer
      第52回日本臨床化学会年次学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      20120906-08
  • [Presentation] Fukushima Daiichi Nuclear Disaster & Radiation Health Risk Management2012

    • Author(s)
      Shunichi Yamashita
    • Organizer
      The Endocrine Society's 94thAnnual Meeting & Expo
    • Place of Presentation
      Houston, USA
    • Year and Date
      20120723-26
  • [Presentation] 福島原発事故と医療人2012

    • Author(s)
      山下俊一
    • Organizer
      第8回日本消化管学会総会学術総会
    • Place of Presentation
      仙台
    • Year and Date
      20120210-11
  • [Presentation] 福島原発事故と医療人;放射線災害医療と健康リスク管理の諸課題2012

    • Author(s)
      山下俊一
    • Organizer
      第29回日本ストーマ・排泄リハビリテーション学会
    • Place of Presentation
      郡山
    • Year and Date
      20120203-04
  • [Presentation] 福島原発事故と放射線健康リスク管理2012

    • Author(s)
      山下俊一
    • Organizer
      日本頭頸部外科学会
    • Place of Presentation
      福島
    • Year and Date
      20120126-27
  • [Presentation] 福島原発事故と放射線健康リスク管理2012

    • Author(s)
      山下俊一
    • Organizer
      57回日本生殖医学会学術講演会・総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-11-09
  • [Presentation] 福島原発事故と放射線健康リスク管理2012

    • Author(s)
      山下俊一
    • Organizer
      第53回日本肺癌学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2012-11-08
  • [Presentation] 福島原発事故と放射線健康リスク管理:チェルノブイリの経験を生かして2012

    • Author(s)
      山下俊一
    • Organizer
      第4回東大エネルギー・環境シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-11-02
  • [Presentation] 福島原発事故と放射線健康リスク管理2012

    • Author(s)
      山下俊一
    • Organizer
      第90回日本形成外科学会九州支部学術集会
    • Place of Presentation
      大村
    • Year and Date
      2012-10-20
  • [Presentation] 福島原発事故と健康リスク;県民健康管理調査事業について2012

    • Author(s)
      山下俊一
    • Organizer
      第52回日本リンパ網内系学会総会
    • Place of Presentation
      福島
    • Year and Date
      2012-06-14
  • [Presentation] 放射線災害医療と健康リスク管理2012

    • Author(s)
      山下俊一
    • Organizer
      第60回日本輸血・細胞治療学会総会
    • Place of Presentation
      福島
    • Year and Date
      2012-05-25
  • [Presentation] 放射線被ばく医療」オーバービュー2012

    • Author(s)
      山下俊一
    • Organizer
      第52回日本呼吸器学会学術講演会シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2012-04-21
  • [Presentation] 原子力災害医療と健康リスク管理2012

    • Author(s)
      山下俊一
    • Organizer
      第71回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-04-14
  • [Presentation] Molecular epidemiology study of radiation-induced papillary thyroid carcinoma after Chernobyl2011

    • Author(s)
      サエンコ ウラジミール
    • Organizer
      第54回日本甲状腺学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20111121-23
  • [Presentation] 放射線と甲状腺:チェルノブイリの教訓から福島原発事故を考える2011

    • Author(s)
      山下 俊一
    • Organizer
      第54回日本甲状腺学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20111121-23
  • [Presentation] チェルノブイリ組織バンク2011

    • Author(s)
      伊東 正博、中島正 洋、山下 俊一、et al
    • Organizer
      第54回日本甲状腺学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20111121-23
  • [Presentation] チェルノブイリ周辺の小児甲状腺癌の病理組織学的特徴2011

    • Author(s)
      伊東 正博、中島 正洋、山下 俊一、et al
    • Organizer
      第54回日本甲状腺学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20111121-23
  • [Presentation] チェルノブイリ周辺地区における甲状腺結節の長期的予後についての臨床疫学研究2011

    • Author(s)
      林田 直美、山下 俊一、高村 昇, et al
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸
    • Year and Date
      20111117-19
  • [Presentation] 福島第一原子力発電所及びチェルノブイリ原子力発電所周辺の環境放射能レベル2011

    • Author(s)
      平良 文亨、林田 直美、山下 俊一、工藤崇、松田 尚樹、高橋 純平、グテビッチ アレキサンダー、カズロフスキー アレキサンダー、高村 昇
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸
    • Year and Date
      20111117-19
  • [Presentation] Comparative pathological analysis of papillary thyroid carcinoma in age-matched groups of patients born before and after Chernobyl2011

    • Author(s)
      T. Bogdanova, V. Saenko, V.A. LiVolsi, S. Yamashita
    • Organizer
      7thNCRI Cancer Conference
    • Place of Presentation
      Liverpool, UK
    • Year and Date
      20111106-09
  • [Presentation] Molecular epidemiology study of Chernobyl thyroid cancer2011

    • Author(s)
      V. Saenko, S. Yamashita, et al
    • Organizer
      14thInternational Congress of Radiation Research
    • Place of Presentation
      Warsaw, Poland
    • Year and Date
      20110828-0901
  • [Presentation] Radiation exposure and thyroid carcinogenesis2011

    • Author(s)
      Norisato Mitsutake
    • Organizer
      Korean Thyroid Association Meeting
    • Place of Presentation
      Daegu, Korea
    • Year and Date
      20110819-20
  • [Presentation] 放射線誘発がん研究の現状と課題;チェルノブイリの教訓から福島原発事故を考える2011

    • Author(s)
      山下 俊一
    • Organizer
      第29回内分泌代謝学サマーセミナー
    • Place of Presentation
      仙台
    • Year and Date
      20110707-09
  • [Presentation] Molecular genetic signatures of radiation-related thyroid cancer2011

    • Author(s)
      サエンコ ウラジミール、高橋 めい子、ログノビッチ タチアナ、光武 範吏、高村昇、松 田 文彦、山下 俊一
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      20110421-23
  • [Presentation] Norisato Mitsutake, Noboru Takamura, Fumihiko Matsuda, Shunichi Yamashita, Molecular signatures of radiation-induced thyroid cancer2010

    • Author(s)
      Vladimir Saenko, et al
    • Organizer
      International Workshop on Radiation Epidemiology and Radiobiology
    • Place of Presentation
      Nagasaki
    • Year and Date
      20101129-30
  • [Presentation] Molecular epidemiology study of papillary thyroid carcinoma developing after internal exposure to radioiodine in Chernobyl2010

    • Author(s)
      ウラジミール サエンコ
    • Organizer
      第53回日本甲状腺学会学術集会
    • Place of Presentation
      長崎
    • Year and Date
      20101111-13
  • [Presentation] Molecular signatures of radiation-related thyroid cancer2010

    • Author(s)
      サエンコ ウラジミール、高橋 めい子、ログノビッチ タチアナ、光武 範吏、松 田 文彦、山下 俊一
    • Organizer
      第53回日本甲状腺学会学術集会
    • Place of Presentation
      長崎
    • Year and Date
      20101111-13
  • [Presentation] Iodine thyroid blocking in nuclear and radiological emergencies2010

    • Author(s)
      Shunichi Yamashita
    • Organizer
      14thInternational Thyroid Congress
    • Place of Presentation
      Paris, France
    • Year and Date
      20100911-16
  • [Presentation] Radiation emergency medicin2010

    • Author(s)
      Akira Ohtsuru
    • Organizer
      125th-Anniversary Conference on Biomedical Sciences between SPB-MAPO and Nagasaki University
    • Place of Presentation
      St.Petersburg, Russia
    • Year and Date
      2010-06-10
  • [Presentation] Molecular epidemiological study of radiation-induced thyroid cancer2010

    • Author(s)
      Vladimir Saenko
    • Organizer
      125th-Anniversary Conference on Biomedical Sciences between SPB-MAPO and Nagasaki University
    • Place of Presentation
      St.Petersburg, Russia
    • Year and Date
      2010-06-10
  • [Remarks]

    • URL

      http://www-sdc.med.nagasaki-u.ac.jp/drms/

  • [Remarks]

    • URL

      http://www-sdc.med.nagasaki-u.ac.jp/dhrc/

URL: 

Published: 2014-08-29  

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