2012 Fiscal Year Final Research Report
Drug-response pathway analysis methods based on network analysis
| Project/Area Number |
22300099
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MIYANO Satoru 東京大学, 医科学研究所, 教授 (50128104)
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| Co-Investigator(Kenkyū-buntansha) |
IMOTO Seiya 東京大学, 医科学研究所, 准教授 (10345027)
YAMAGUCHI Rui 東京大学, 医科学研究所, 講師 (90380675)
NAGASAKI Masao 東京大学, 医科学研究所, 准教授 (90396862)
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| Co-Investigator(Renkei-kenkyūsha) |
WATANABE Kenji 慶應義塾大学, 医学部, 准教授 (70191757)
GOTOH Noriko 東京大学, 医科学研究所, 特任准教授 (10251448)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 遺伝子ネットワーク / 薬剤応答パスウェイ / 動的モデル / シミュレーション / パ スウェイ解析 / ベイジアンネットワーク / ペトリネット / 状態空間モデル |
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| Research Abstract |
We developed computational/statistical methods for inferring abstract network models from time-course or case-control gene expression data of drug-responses. We also developed a series of knowledge processing technologies for efficiently constructing and systematically validating dynamic models from the literature information on biomolecular interactions. Bayesian network and state space model are employed for the former and an extended Petri net is used for the latter.
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[Journal Article] Vasohibin-1 is identified as a master-regulator of endothelial cell apoptosis using gene network analysis2013
Author(s)
Affara M, Sanders D, Araki H, Tamada Y, Dunmore B, Humphreys S, Imoto S, Savoie C, Miyano S, Kuhara S, Print C, Charnock-Jones DS
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Journal Title
BMC Genomics
Volume: 14(1)
Pages: 23
DOI
Peer Reviewed
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[Journal Article] Cell cycle gene networks are associated with melanoma prognosis2012
Author(s)
Wang L, Hurley D, Watkins W, Araki H, Tamada Y, Muthukaruppan A, Ranjard L, Derkac E, Imoto S, Miyano S, Crampin E, Print C
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Journal Title
PLoS One
Volume: 7(4)
Pages: e34247
DOI
Peer Reviewed
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[Journal Article] Epidermal growth factor receptor tyrosine kinase defines criticalprognostic genes of stage I lung adenocarcinoma2012
Author(s)
Yamauchi M, Yamaguchi R, Nakata A, Kohno T, Nagasaki M, Shimamura T, Imoto S, Saito A, Ueno K, Hatanaka Y, Yoshida R, Higuchi T, Nomura M, Beer DG, Yokota J, Miyano S, Gotoh N
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Journal Title
PLoS One
Volume: 7(9)
Pages: e43923
DOI
Peer Reviewed
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