2012 Fiscal Year Final Research Report
Construction of protein-structure prediction method based on liquid state theory
| Project/Area Number |
22300100
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKADA Shoji 京都大学, 大学院・理学研究科, 教授 (60304086)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 蛋白質 / フォールディング / 立体構造予測 / 水和 / 自由エネルギー関数 |
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| Research Abstract |
We analyze the structural stabilities of proteins in aqueous and nonpolar environments, thus revealing their differences. Free-energy functions are constructed for these proteins on the basis of liquid-state theories and their usefulness is demonstrated. After generating a number of candidate structures using typical bioinformatics techniques, we select the structure giving the free-energy function for a protein in aqueous environment: Promising results are obtained for several proteins tested.
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