2012 Fiscal Year Final Research Report
Molecular basisfor the integral regulatory system ofnutritional homeostasis and its role in the life-style related diseases.
Project/Area Number |
22300237
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied health science
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Research Institution | The University of Tokushima |
Principal Investigator |
TAKETANI Yutaka 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30263825)
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Research Collaborator |
WATARI Eriko 徳島大学, 大学院・栄養生命科学教育部, 大学院生
KITAMURA Tomoyo 徳島大学, 大学院・栄養生命科学教育部, 大学院生
SHIOTA Asuka 徳島大学, 大学院・栄養生命科学教育部, 大学院生
TAN Vu Van 徳島大学, 大学院・栄養生命科学教育部, 大学院生
AMO Kikuko 徳島大学, 大学院・栄養生命科学教育部, 大学院・生
OHMINAMI Hirokazu 徳島大学, 大学院・栄養生命科学教育部, 大学院・生
HORIE Daisuke 徳島大学, 大学院・栄養生命科学教育部, 大学院・生
YAMADA Fumiyo 徳島大学, 大学院・栄養生命科学教育部, 大学院・生
TANIMURA Ayako 徳島大学, 大学院・栄養生命科学教育部, 大学院・生
|
Project Period (FY) |
2010 – 2012
|
Keywords | シグナル伝達 / リン、血管内皮機能 / 高リン血症 / 肥満 / 心血管疾患 / 慢性腎臓病 / 生活習慣病 |
Research Abstract |
Although molecular mechanisms for life-style related diseases have been clarified, interaction between nutrients has not been elucidated yet. In this study, we attempted to understand how disturbance of phosphorus metabolism can affect energy metabolism, resulted in various life-style related diseases including obesity, atherosclerosis, diabetes. Here, we identified key molecules to regulate both phosphorus and energy metabolism in cellular levels. In addition, we found that disturbance of phosphorus metabolism can affect energy expenditure and endothelial function in animal model and human study.
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Research Products
(15 results)
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[Journal Article] Thyroid hormones decrease plasma 1a,25-dihydroxyvitamin D levels through transcriptional repression of the renal 25-hydroxyvitamin D-1a-hydroxylase gene (CYP27B1)2013
Author(s)
Kozai M, Ishiguro M, Harada N.Masuda M, Kagawa T, Takei Y, Ohtani A, Nakahashi O, Ikeda S, Taketani Y.Miyamoto K, Takeyama K, Kato S, Takeda E
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Journal Title
Endocrinology
Volume: 154
Pages: 609-622
DOI
Peer Reviewed
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[Journal Article] Up-regulation of stanniocalcin 1 expression by 1,25(OH)2D3 and PTH in renal proximal tubular cells2012
Author(s)
Hung NT, Yamamoto H, Takei Y, Masuda M, Otani A, Kozai M, Ikeda S, Nakahashi O, Tanaka S, Taketani Y, Takeda E
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Journal Title
J Clin Biochem Nutr
Volume: 50
Pages: 227-233
DOI
Peer Reviewed
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[Journal Article] Dietary phosphate restriction ameliorates endothelial dysfunction in adenine-induced kidney disease rats2012
Author(s)
Vu Van T, Watari E, Taketani Y, Kitamura T, Shiota A, Tanaka T, Tanimura A, Harada N, Nakaya Y, Yamamoto H, Miyamoto K, Takeda E
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Journal Title
J Clin Biochem Nutr
Volume: 51
Pages: 27-32
Peer Reviewed
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[Journal Article] FGF21 by both fasting and feeding signals: Is FGF21 a nutritional adaptation factor2011
Author(s)
Uebanso T, Taketani Y, Yamamoto H,Amo K, Ominami H, Arai H, Takei Y, Masuda M, Tanimura A, Harada N, Yamanaka-Okumura H, Takeda E. Paradoxical regulation of human
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Journal Title
PLoS One
Volume: 6
Pages: 22976
DOI
Peer Reviewed
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[Journal Article] Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis.2011
Author(s)
Tanimura A, Yamada F, Saito A, Ito M, Kimura T, Anzai N, Horie D, Yamamoto H, Miyamoto K, Taketani Y, Takeda E
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Journal Title
J Med Invest
Volume: 59
Pages: 140-147
Peer Reviewed
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[Journal Article] Regulation of renal sodium-dependent phosphate co-transporter genes (Npt2a and Npt2c) by all-trans-retinoic acid and its receptors2010
Author(s)
Masuda M, Yamamoto H, Kozai M, Tanaka S, Ishiguro M, Takei Y, Nakahashi O, Ikeda S, Uebanso T, Taketani Y, Segawa H, Miyamoto K, Takeda E.
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Journal Title
Biochem J.
Volume: 492
Pages: 583-592
DOI
Peer Reviewed
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[Journal Article] An apical expression signal of the renal type IIc Na+-dependent phosphate cotransporter in renal epithelial cells.2010
Author(s)
Ito M, Sakurai A, Hayashi K, Ohi A, Kangawa N, Nishiyama T, Sugino S, Uehata Y, Kamahara A, Sakata M, Tatumi S, Kuwahata M, Taketani Y,Segawa H, Miyamoto K.
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Journal Title
Am J Physiol Renal Physiol
Volume: 299
Pages: F243-F254
DOI
Peer Reviewed
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[Journal Article] Thyroid hormones regulate phosphate homeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter (Npt2a) gene2010
Author(s)
Ishiguro M, Yamamoto H, Masuda M, Kozai M, Takei Y, Tanaka S, Sato Y, Segawa H, Taketani Y, Arai H, Miyamoto K, Takeda E
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Journal Title
Biochem J.
Volume: 427
Pages: 161-169
DOI
Peer Reviewed
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