2012 Fiscal Year Final Research Report
Molecular mechanisms regulating dissemination and collective migration of cancer cells
| Project/Area Number |
22300324
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Akita University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 播種 / 集団移動 / チロシンリン酸化 / 細胞接触阻止 / 神経膠腫 |
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| Research Abstract |
We identified SKAP2 as a tyrosine-phosphorylated protein in glioma. Unexpectedly, SKAP2 suppressed invasion of glioma cell through down-regulating actin assembly and stabilizing the cell membrane. On the other hand, SKAP2 accelerates invasion of macrophages via association with the specific adaptor, which suggests SKAP2 promotes inflammatory cancers by activation of cancer associated macrophages. In addition, we identified that N-cadherin and Nm23H1 plays pivotal roles for establishment of "contact inhibition of locomotion", which is a fundamental mechanism of collective migration of the cells.
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Research Products
(18 results)
