2012 Fiscal Year Final Research Report
Elucidation of protumor/antitumor immune regulation mechanisms based on host versus cancer stem cell responses
| Project/Area Number |
22300331
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor immunology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Hidemitsu 北海道大学, 遺伝子病制御研究所, 准教授 (40360531)
WAKITA Daiko 北海道大学, 遺伝子病制御研究所, 助教 (30555404)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 癌幹細胞 / IL-17 / 腫瘍内微小環境 / CD133 / TGF-ss |
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| Research Abstract |
In the present research, we investigated the mechanisms of protumor immune regulation in tumor microenvironment. As a result, we found that 〓 〓T cells were predominant IL-17-producing cells in tumor-bearing host, which promoted tumorigenesis through the angiogenesis. In addition, we demonstrated that the tumor-initiating capacity of CD133^+ cells was blocked by depleting Treg, which were induced in TGF-ss-dependent manner, suggesting that CD133^+ cancer initiating cells suppress CTL-mediated immunosurveillance. In the near future, overcoming the protumor immunity caused by cancer stem cells, which induces effective tumor-antigen specific Th1 cells, would be a promising strategy for cancer immunotherapy and prevention of recurrence.
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[Journal Article] Toll-like receptor-dependent IL-12 production by dendritic cells is required for activation of natural killer cell-mediated Type-1 immunity induced by Chrysanthemum coronarium L2011
Author(s)
Tanaka S, Koizumi S, Masuko K, Makiuchi N, Aoyagi Y, Quivy E, Mitamura R, Kano T, Ohkuri T, Wakita D, Chamoto K, Kitamura H, Nishimura T
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Journal Title
Int Immunopharmacol
Volume: 11(2)
Pages: 226-32
DOI
Peer Reviewed
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[Journal Article] The extract of Japanese soybean, Kurosengoku activates the production of IL-12 and IFN-γ byDC or NK1.1(+) cells in a TLR4-andTLR2-dependent manner2011
Author(s)
Tanaka S, Koizumi S, Makiuchi N, Aoyagi Y, Quivy E, Mitamura R, Kano T, Wakita D, Chamoto K, Kitamura H, Nishimura T
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Journal Title
Cell Immunol
Volume: 266(2)
Pages: 135-42
DOI
Peer Reviewed
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