2012 Fiscal Year Final Research Report
Physiological and pathological analyses of cell adhesion molecules towards the development of diagnostic markers of human cancer
| Project/Area Number |
22300336
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor diagnosis
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITO Akihiko 近畿大学, 医学部, 教授 (80273647)
SAKURAI Mika 東京大学, 医科学研究所, 助教 (80508359)
GOTO Akiteru 秋田大学, 大学院・医学系研究科, 教授 (90317090)
MATSUBARA Daisuke 東京大学, 医科学研究所, 講師 (80415554)
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| Project Period (FY) |
2010 – 2012
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| Keywords | がんの個性診断 |
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| Research Abstract |
Physiological and pathological roles of cell adhesion molecules in cancer development and progression were analyzed to establish novel molecular markers of human cancer. We found that a splicing variant of a cell adhesion molecule CADM1 was expressed exclusively in small cell lung cancer (SCLC), providing a candidate diagnostic marker of SCLC. We also found that CADM1 could cross-talk with the MET signaling and may play a role in acquired resistance of lung adenocarcinoma against EGFR-TKItreatment.
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