2012 Fiscal Year Final Research Report
Effects of chemical exposure on male reproductive organogenesis and functions
| Project/Area Number |
22310040
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YOSHINAGA Jun 東京大学, 大学院・新領域創成科学研究科, 准教授 (70222396)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Yutaro 名古屋市立大学, 大学院・医学研究科, 准教授 (40238134)
KOJIMA Yoshiyuki 名古屋市立大学, 大学院・医学研究科, 講師 (60305539)
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| Research Collaborator |
MIZUMOTO Yoshifumi , 自衛隊中央病院産婦人科, 部長
TOKUOKA Susumu , 徳岡レディースクリニック, 院長
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| Project Period (FY) |
2010 – 2012
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| Keywords | フタル酸エステル / ピレスロイド / バイオマーカー / 肛門性器間距離 / 精液所見 |
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| Research Abstract |
Effects of environmental exposure to some selected chemicals on male reproductive organs and functions were examined in non-exposed general subjects. Urinary concentration of the target chemicals and/or their metabolites was used as a biomarker of exposure and anogenital distance (AGD) at birth and semen parameters was used for the assessment of effect on fetal and adult exposure to the target chemicals, respectively. In utero exposure to phthalate di(2-ethylhexyl) was found to shorten AGD of male newborn. Exposure to pyrethroid insecticides was found to decrease semen motility in male partners of infertile couples. These findings were assumed to be related to interference on testosterone action or production due to exposure to these chemicals at environmental levels.
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