• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2012 Fiscal Year Final Research Report

A study on polymorphisms associated with obesity and lipid profile in the Oceanic populations

Research Project

  • PDF
Project/Area Number 22370084
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical anthropology
Research InstitutionUniversity of Tsukuba

Principal Investigator

OHASHI Jun  筑波大学, 医学医療系, 准教授 (80301141)

Co-Investigator(Kenkyū-buntansha) KIMURA Ryosuke  琉球大学, 医学部, 准教授 (00453712)
NISHIDA Nao  独立行政法人国立国際医療センター, 肝炎・免疫研究センター, 上級研究員 (50456109)
NAKAYAMA Kazuhiro  自治医科大学, 医学部, 講師 (90433581)
Project Period (FY) 2010 – 2012
Keywordsオセアニア / 肥満 / 多型 / 倹約遺伝子 / BMI / 脂質代謝 / オーストロネシア語族
Research Abstract

A SNP located upstream of ADRB2, rs34623097, showed the strongest association with obesity in a logistic regression analysis adjusted for age, sex, and population (P = 5.6 x 10-4, odds ratio [OR] = 2.5, 95% confidence interval [CI] = 1.5-4.2).To study the origin of Polynesians and the gene flow from Polynesian ancestors to indigenous Melanesians, a 48-bp variable number of tandem repeat (VNTR) in exon 3 of the dopamine D4 receptor (DRD4) gene was investigated for six Austronesian (AN)-speaking populations. Our results provide evidence of gene flow from Polynesian ancestors to indigenous Melanesians while Polynesian ancestors passed through Melanesia.A candidate gene association analysis on 11 metabolic traits of 5,810 East Asians revealed that rs1057001, a T/A transversion polymorphism in 3'untranslated region (UTR) of TRIB2, was strongly associated with visceral fat area (VFA) and waist circumference adjusted for body mass index (P = 2.7 × 10(-6) and P = 9.0 × 10(-6), respectively).

  • Research Products

    (28 results)

All 2013 2012 2011 2010 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] Positive natural selection of TRIB2, a novel gene that influences visceral fat accumulation, in East Asia2013

    • Author(s)
      Nakayama K, Ogawa A, Miyashita H, Tabara Y, Igase M, Kohara K, Miki T, Kagawa Y, Yanagisawa Y, Katashima M, Onda T, Okada K, Fukushima S, Iwamoto S
    • Journal Title

      Hum Genet

      Volume: 132 Pages: 201-217

    • Peer Reviewed
  • [Journal Article] Hypertension Susceptibility Gene Prevalence in the Pacific Islands and Associations with Hypertension in Melanesia.2013

    • Author(s)
      Furusawa T, Naka I, Yamauchi T, Natsuhara K, Eddie R, Kimura R, Nakazawa M, Ishida T, Inaoka T, Matsumura Y, Ataka Y, Ohtsuka R, Ohashi J
    • Journal Title

      Journal of Human Genetics

      Volume: 58 Pages: 142-149

    • Peer Reviewed
  • [Journal Article] Plasma resistin is associated with single nucleotide polymorphisms of a possible resistin receptor, the decorin gene, in the general Japanese population.2013

    • Author(s)
      Onuma H, Tabara Y, Kawamura R, Ohashi J, Nishida W, Takata Y, Ochi M, Nishimiya T, Kawamoto R, Kohara K, Miki T, Osawa H
    • Journal Title

      Diabetes

      Volume: 62 Pages: 649-652

    • Peer Reviewed
  • [Journal Article] DRD4 VNTR polymorphism in Oceanic populations.2012

    • Author(s)
      Naka I, Ohashi J, Kimura R, Furusawa T, Yamauchi T, Nakazawa M, Natsuhara K, Ataka Y, Nishida N, Ishida T, Inaoka T, Matsumura Y, Ohtsuka R
    • Journal Title

      Anthropological Science

      Volume: 120 Pages: 151-155

    • Peer Reviewed
  • [Journal Article] Association of CTXN3-SLC12A2 polymorphisms and schizophrenia in a Thai population2012

    • Author(s)
      Panichareon B, Nakayama K, Iwamoto S, Thurakitwannakarn W, Sukhumsirichart W
    • Journal Title

      Behav Brain Funct

      Volume: 8 Pages: 27

    • Peer Reviewed
  • [Journal Article] OPCML gene as a schizophrenia susceptibility locus in Thai population2012

    • Author(s)
      Panichareon B, Nakayama K, Thurakitwannakarn W, Iwamoto S, Sukhumsirichart W
    • Journal Title

      J Mol Neurosci

      Volume: 46 Pages: 373-377

    • Peer Reviewed
  • [Journal Article] The history of human populations in the Japanese Archipelago inferred from genome-wide SNP data with a special reference to the Ainu and the Ryukyuan populations2012

    • Author(s)
      Japanese Archipelago Human Population Genetics Consortium members: Jinam T, Nishida N, Hirai M, Kawamura S, Oota H, Umetsu K, Kimura R, Ohashi J, Tajima A, Yamamoto T, Tanabe H, Mano S, Suto Y, Kaname T, Naritomi K, Yanagi K, Niikawa N, Omoto K, Tokunaga
    • Journal Title

      Journal of Human Genetics

      Volume: 57 Pages: 787-795

    • Peer Reviewed
  • [Journal Article] High prevalence of an anti-hypertriglyceridemic variant of the MLXIPL gene in Central Asia2011

    • Author(s)
      Nakayama K, Yanagisawa Y, Ogawa A, Ishizuka Y, Munkhtulga L, Charupoonphol P, Supannnatas S, Kuartei S, Chimedregzen U, Koda Y, Ishida T, Kagawa Y, Iwamoto S
    • Journal Title

      J Hum Genet

      Volume: 56 Pages: 828-833

    • Peer Reviewed
  • [Journal Article] No evidence for strong recent positive selection favoring the 7 repeat allele of VNTR in the DRD4 gene2011

    • Author(s)
      Naka I, Nishida N, Ohashi J
    • Journal Title

      PLoS One

      Volume: 6 Pages: e24410

    • Peer Reviewed
  • [Journal Article] Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1A is associated with BMI in Tongans.2011

    • Author(s)
      Myles S, Lea RA, Ohashi J, Chambers GK, Weiss JG, Hardouin E, Engelken J, Macartney-Coxson DP, Eccles DA, Naka I, Kimura R, Inaoka T, Matsumura Y, Stoneking M
    • Journal Title

      BMC Medical Genetics

      Volume: 12 Pages: 10

    • Peer Reviewed
  • [Journal Article] The serum leptin level and body mass index in Melanesian and Micronesian Solomon Islanders: Focus on genetic factors and urbanization.2011

    • Author(s)
      Furusawa T, Naka I, Yamauchi T, Natsuhara K, Kimura R, Nakazawa M, Ishida T, Nishida N, Eddie R, Ohtsuka R,Ohashi J
    • Journal Title

      American Journal of Human Biology

      Volume: 23 Pages: 435-444

    • Peer Reviewed
  • [Journal Article] The impact of natural selection on an ABCC11 SNP determining earwax type.2011

    • Author(s)
      Ohashi J, Naka I, Tsuchiya N
    • Journal Title

      Molecular Biology and Evolution

      Volume: 28 Pages: 849-857

    • Peer Reviewed
  • [Journal Article] A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle.2010

    • Author(s)
      Nakayama K, Bayasgalan T, Tazoe F, Yanagisawa Y, Gotoh T, Yamanaka K, Ogawa A, Munkhtulga L, Chimedregze U, Kagawa Y, Ishibashi S, Iwamoto S
    • Journal Title

      Hum Genet

      Volume: 127 Pages: 685-690

    • Peer Reviewed
  • [Journal Article] The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders.2010

    • Author(s)
      Furusawa T, Naka I, Yamauchi T, Natsuhara K, Kimura R, Nakazawa M, Ishida T, Inaoka T, Matsumura Y, Ataka Y, Nishida N, Tsuchiya N, Ohtsuka R, Ohashi J
    • Journal Title

      Human Genetics

      Volume: 127 Pages: 287-294

    • Peer Reviewed
  • [Journal Article] Regulatory SNP in the RBP4 gene modified the expression in adipocytes and associated with BMI2010

    • Author(s)
      Munkhtulga L, Nagashima S, Nakayama K, Utsumi N, Yanagisawa Y, Gotoh T, Omi T, Kumada M, Zolzaya K, Lkhagvasuren T, Kagawa Y, Fujiwara H, Hosoya Y, Hyodo M, Horie H, Kojima M, Ishibashi S, Iwamoto S
    • Journal Title

      Obesity (Silver Spring)

      Volume: 18 Pages: 1006-1014

    • Peer Reviewed
  • [Journal Article] Variations in the coding region of the agouti signaling protein gene do not explain agouti/non-agouti phenotypes in macaques2010

    • Author(s)
      Nakayama K, Shotake T, Takenaka O, Ishida T
    • Journal Title

      J Mammal Evol

      Volume: 17 Pages: 211-214

    • Peer Reviewed
  • [Journal Article] The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels, and lower HOMA-IR in Japanese population.2010

    • Author(s)
      Onuma H, Tabara Y, Kawamoto R, Shimizu I, Kawamura R, Takata Y, Nishida W, Ohashi J, Miki T, Kohara K, Makino H, Osawa H
    • Journal Title

      Journal of Human Genetics

      Volume: 55 Pages: 600-604

    • Peer Reviewed
  • [Journal Article] A at Single Nucleotide Polymorphism-358 Is Required for G at -420 to Confer the Highest Plasma Resistin in the General Japanese Population.2010

    • Author(s)
      Onuma H, Tabara Y, Kawamura R, Tanaka T, Ohashi J, Nishida W, Takata Y, Ochi M, Yamada K, Kawamoto R, Kohara K, Miki T, Makino H, Osawa H
    • Journal Title

      PLoS One

      Volume: 5(3) Pages: e9718

    • Peer Reviewed
  • [Journal Article] Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population?2010

    • Author(s)
      Osawa H, Tabara Y, Ohashi J, Kawamura , Onuma H, Makino H
    • Journal Title

      Diabetologia

      Volume: 53 Pages: 795-797

    • Peer Reviewed
  • [Journal Article] A functional SNP upstream of the beta-2 adrenergic receptor gene (ADRB2) is associated with obesity in Oceanic populations

    • Author(s)
      Naka I, Hikami K, Nakayama K, Koga M, Nishida N, Kimura R, Furusawa T, Natsuhara K, Yamauchi T, Nakazawa M, Ataka Y, Ishida T, InaokaT, Iwamoto S, Matsumura Y, Ohtsuka R, Tsuchiya N, Ohashi J
    • Journal Title

      International Journal of Obesity

      Volume: (in press)

    • DOI

      doi:10.1038/ijo.2012.206

    • Peer Reviewed
  • [Presentation] Significant association of LPL polymorphisms with HDL-cholesterol level in Tongan adults2012

    • Author(s)
      Naka et al.
    • Organizer
      The American Society of Human Genetics 62th Annual Meeting
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2012-11-09
  • [Presentation] β2アドレナリン受容体遺伝子(ADRB2) 上流領域SNPの進化遺伝学的解析2012

    • Author(s)
      中伊津美,他
    • Organizer
      日本人類学会第66回大会
    • Place of Presentation
      慶応大学日吉キャンパス、日吉、神奈川
    • Year and Date
      2012-11-04
  • [Presentation] トンガ人集団におけるLPL遺伝子多型とHDLコレステロールとの関連2012

    • Author(s)
      中伊津美,他
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      新宿、東京
    • Year and Date
      2012-10-25
  • [Presentation] オセアニア集団におけるDRD4 遺伝子 VNTR 多型の解析2011

    • Author(s)
      中伊津美,他
    • Organizer
      日本人類遺伝学会第56回大会
    • Place of Presentation
      幕張、千葉
    • Year and Date
      2011-11-11
  • [Presentation] オセアニア集団におけるβアドレナリン受容体プロモーター多型と肥満との関連2011

    • Author(s)
      中伊津美,他
    • Organizer
      日本人類学会第65回大会
    • Place of Presentation
      那覇、沖縄
    • Year and Date
      2011-11-04
  • [Presentation] The VNTR polymorphism of the dopamine D4 receptor (DRD4) gene in Oceanic populations2011

    • Author(s)
      Naka et al.
    • Organizer
      The American Society of Human Genetics 60th Annual Meeting, The American Society of Human Genetics 60th Annual Meeting
    • Place of Presentation
      Washington, USA
    • Year and Date
      2011-11-04
  • [Presentation] Significant association of ADRB2 Glu27Gln polymorphism with triglyceride level2011

    • Author(s)
      Naka et al.
    • Organizer
      The American Society of Human Genetics 61th Annual Meeting
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2011-10-14
  • [Remarks]

    • URL

      http://www.md.tsukuba.ac.jp/community-med/publicmd/GE/CCP004.html

URL: 

Published: 2014-08-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi