2012 Fiscal Year Final Research Report
The physiological polymorphism of atherosclerosis investigated by genetic and environmental factors
| Project/Area Number |
22370090
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied anthropology
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| Research Institution | Nagasaki University |
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Principal Investigator |
MAEDA Takahiro 長崎大学, 医歯薬学総合研究科, 教授 (40284674)
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| Co-Investigator(Kenkyū-buntansha) |
NAKASHIMA Kenichirou 長崎大学, 医歯薬学総合研究科, 教授 (30039656)
TAKAMURA Noboru 長崎大学, 医歯薬学総合研究科, 教授 (30295068)
YAMASAKI Hironori 長崎大学, 保健・医療推進センター, 保健・医療推進センター (40346953)
KUSANO Yousuke 長崎大学, 医歯薬学総合研究科, 客員研究員 (70325637)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 動脈硬化 / 遺伝子多型 / 頸動脈内中膜複合体厚(CIMT) / 心臓足首血管指数(CAVI) |
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| Research Abstract |
Most cases of atherosclerosis result from the interactions of multiple genetic and environmental factors. To investigate the association between gene polymorphisms and clinical parameter of atherosclerosis such as carotid intima-media thickness (CIMT) and cardio-ankle vascular index (CAVI), we conducted cross-sectional study of 1,295 Japanese (502 men and 793 women) who participated in a general health check in western rural community of the Goto Islands from 2000 to 2012. We analyzed polymorphisms of four genes such as MTHFR(rs1801133), HDAC4(rs3791398), CARKL(rs465563), and Adiponectin(rs1501299) which were reported the significant relation with atherosclerosis.The genotype distributions of four genes were as follows, MTHFR (CC: 43.2%, CT: 46.5%and TT: 10.3%), Adiponectin(GG: 53.7%, GT: 38.9%, and TT: 7.4%), HDAC4(GG: 80.4%, GA: 18.5%, and AA: 1.1%), and CARKL(GG: 12.7%, GA: 44.5%, and AA: 42.8%). No significant association between genotype and CAVI nor CIMT was observed. Next, we categorized into five groups based on the number of risky genotype and analyzed the association according to a group. Although no significant association was observed both in CIMT and CAVI, positive tendency was observed in CAVI. Further investigation with large number of participants is necessary to clarify the association between gene polymorphism and atherosclerosis.
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Research Products
(16 results)
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[Journal Article] Lack of an association between E-selectin gene polymorphisms and the risk of Kawasaki disease2012
Author(s)
Shirakawa T, Ikeda K, Nishimura S, Kuniba H, Nakashima K, Motomura H, Mizuno Y, Zaitsu M, Nakazato M, Maeda T, Hamasaki Y, Hara T, Moriuchi H
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Journal Title
Pediar Int
Volume: 54
Pages: 455-460
DOI
Peer Reviewed
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[Journal Article] The association between atherosclerosis and plasma homocysteine concentration in the general population residing on remote islands in Japan2011
Author(s)
Nakazato M, Takamura N, Kadota K, Yamasaki H, Mukae H, Kusano Y, Nakashima K, Ozono Y, Aoyagi K, Kohno S, and Maeda T
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Journal Title
ACTA MEDICA NAGASAKIENSIA
Volume: 55
Pages: 47-54
Peer Reviewed
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[Journal Article] Leptin to high-molecular-weight adiponectinratio is independently correlated with carotid intima-media thickness in men, but not in women2010
Author(s)
Takamura N, Hayashida N, Hagane K, Kadota K, Yamasaki H, Abiru N, Ozono Y, Kamihira S, Aoyagi K, Ishibashi K, Nakazato M, and Maeda T
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Journal Title
Biomarkers
Volume: 15(4)
Pages: 340-4
DOI
Peer Reviewed
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