2012 Fiscal Year Final Research Report
Screening of new reactions for lipid conversion and development of production processes for functional lipids
| Project/Area Number |
22380051
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Kyoto University |
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Principal Investigator |
SAKURADANI Eiji 京都大学, 大学院・農学研究科, 助教 (10362427)
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| Co-Investigator(Kenkyū-buntansha) |
ANDO Akinori 京都大学, 生理化学研究ユニット, 特定助教 (10537765)
HAGISHITA Tairo 京都大学, 大学院・農学研究科, 特定准教授 (20432346)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 油脂発酵 / Mortierella alpina / アラキドン酸 / 高度不飽和脂肪酸 / ステロール |
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| Research Abstract |
We worked on the research related with filamentous fungus Mortierella alpina which produces microbial oils rich in beneficial fatty acids such as arachidonic acid and eicosapentaenoic acid. First, we constructed a gene manipulation system of this fungus and enhanced the lipid productivities by metabolic engineering. This stain accumulates not only beneficial fatty acids but also unique sterols. Second, we evaluated enzyme genes involved in sterol biosynthetic pathways to improve sterol productivities by molecular breeding of this fungus.
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