2013 Fiscal Year Final Research Report
Evolutionary dynamics of feline retroviruses
| Project/Area Number |
22380168
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUJIMOTO Hajime 東京大学, 大学院・農学生命科学研究科, 教授 (60163804)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 古代ウイルス学 / 白血病 / 病原性 / 遺伝的多様性 / レトロウイルス |
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| Research Abstract |
We found genetic diversity in FeLV env genes. Phylogenetic tree indicated that FeLV samples were separated into three distinct genetic clusters. A novel recombinant virus, termed FeLV-D, was generated ERV-DC env transduction into FeLV. ERV-DCs are present and hereditary in the domestic cat genome. Two of these ERV-DCs, ERV-DC10 and ERV-DC18 are replication-competent gammaretroviruses. Insertional polymorphism analysis revealed that 38% of domestic cats had ERV-DC10. ERV-DCs behave as donors and/or acceptors in the generation of infectious, recombinant viruses. Furthermore, we discovered a soluble anti-retroviral factor, termed Refrex-1. The host retains Refrex-1 as an anti-retroviral factor which may potentially prevent re-emergence of ERVs and emergence of novel ERV-related viruses in cats. We provide an exciting and unique system in cats to study retrovirus-host coevolution and establish paleovirology in cats.
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[Journal Article] Establishment of a novel feline leukemia virus (FeLV)-negative B-cell cell line from a cat with B-cell lymphoma2011
Author(s)
Mochizuki H, Takahashi M, Nishigaki K, Ide T, Goto-Koshino Y, Watanabe S, Sato H, Sato M, Kotera Y, Fujino Y, Ohno K, Uchida K, Tsujimoto H
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Journal Title
Vet Immunol Immunopathol
Volume: 140(3-4)
Pages: 307-311
DOI
Peer Reviewed
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