2013 Fiscal Year Final Research Report
Basic studies for the genetic diagnoses of hereditary neurological diseases in companion animals
| Project/Area Number |
22380171
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
UCHIDA Kazuyuki 東京大学, 農学生命科学研究科, 准教授 (10223554)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Hiroyuki 東京大学, 大学院・農学生命科学研究科, 教授 (40155891)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 神経疾患 / 伴侶動物 / 遺伝性疾患 / 神経軸索ジストロフィー / 変性性脊髄症 / 壊死性髄膜脳炎 / イヌ / ネコ |
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| Research Abstract |
The research works focused on neuronal diseases in animals that possibly have hereditary etiology to know the pathogenesis and genetic factors. The investigations successfully revealed the causative gene mutation of canine neuroaxonal dystrophy. The studies also revealed the detailed pathogenesis of canine degenerative myelopathy. The mutation of SOD1 gene had a limited role and some additional factors would be necessary for the pathogenesis of the ALS-like-diseases. Throughout the research works, some neurodegenerative disorders such as Alexander-like disease and Globoid cell leukodystrophy have been newly found, and causative genes of the diseases were elucidated. The achievements of the series of research will directory provide useful information to prevent the hereditary neuronal diseases and to product animal models for similar human diseases.
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Research Products
(17 results)
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[Journal Article] Clinical and pathologic features of neuronal ceroid-lipofuscinosis in a ferret (Mustela putorius furo)2011
Author(s)
Nibe, K., Miwa, Y., Matsunaga, S., Uetsuka, K., Nakayama, H., Uchida, K
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Journal Title
Vet Pathol
Volume: 72(11)
Pages: 1495-1499
DOI
Peer Reviewed
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[Journal Article] Neuronal ceroid-lipofuscinosis in long-haired Chihuahuas : clinical, pathological and magnetic resonance imaging findings2010
Author(s)
Nakamoto, Y., Yamato, O., Uchida, K., Nibe, K., Tamura, S., Ozawa, T., Ueoka, N., Nukaya, A., Yabuki, A., Nakaichi, M.
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Journal Title
J. Am. Anim. Hosp. Assoc
Volume: 47(4)
Pages: e64-70
DOI
Peer Reviewed
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[Journal Article] GM2 gangliosidosis variant 0 (Sandhoff-like disease) in a family of toy poodles2010
Author(s)
Tamura, S., Tamura, Y., Uchida, K., Nibe, K., Nakaichi, M., Hossain, M. A., Chang, H. S., Rahman, M. M., Yabuki, A., Yamato, O
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Journal Title
J. Vet. Intern. Med
Volume: 24(5)
Pages: 1013-1019
DOI
Peer Reviewed
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