2012 Fiscal Year Final Research Report
Glucose and lipid metabolism regulated by the endoplasmic reticulum signaling
| Project/Area Number |
22390061
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
OYADOMARI Seiichi 徳島大学, 疾患プロテオゲノム研究センター, 教授 (90502534)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HOSODA Akira 徳島大学, 疾患プロテオゲノム研究セン ター, 特任助教 (50379559)
OYADOMARI Miho 徳島大学, 疾患プロテオゲノム研究セン ター, 特任助教 (00596158)
MIYAKE Masato 徳島大学, 疾患プロテオゲノム研究セン ター, 特任助教 (30588976)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 小胞体 / ストレス / PERK / eIF2α / 代謝 / 骨格筋 / 褐色脂肪細胞 |
|---|
| Research Abstract |
The unfolded protein response (UPR) signal is involved in metabolic regulation. However, the significance of the protein kinase R-like endoplasmic reticulum kinase (PERK) signaling pathway in metabolism remains to be clarified. Our study showthat skeletal muscle-specific PERK activation promotes energy consumption in brown adipose tissue (BAT) and suppresses diet-induced obesity. We reveal that when eIF2αis phosphorylated by PERK, it acts through activating transcription factor 4 (ATF4) to stimulate energy consumption by inducing secretion of the myokine FGF21.
|
Research Products
(7 results)
