2012 Fiscal Year Final Research Report
Intracellular signal transduction of chronic pain in the spinal cord and tempospatial analysis of intercellular bioactive substances
| Project/Area Number |
22390063
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kansai Medical University |
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Principal Investigator |
ITO Seiji 関西医科大学, 医学部, 教授 (80201325)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMURA Shinji 関西医科大学, 医学部, 講師 (70276393)
KATANO Tayo 関西医科大学, 医学部, 講師 (60469244)
YAO Ikuko 関西医科大学, 医学部, 准教授 (60399681)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 慢性疼痛 / 疼痛の神経機構 / NMDA 受容体 / リン酸化カスケード / ミクログリア / プロスタグランジン / 術後鎮痛 |
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| Research Abstract |
We clarified 1) essential roles of Tyr1472 phosphorylation of the NR2B subunit of NMDA glutamate receptors in maintenance of chronic pain and augmentation of nerve injury, 2) phosphorylation cascade, and 3) blockade of migration of activated microglia by prostaglandin E2 and nitric oxide by using animal models of neuropathic pain, postherpetic neuralgia, and peripheral nerve regeneration. We analyzed neural network in the spinal cord with imaging mass spectrometry and two-photon microscopy. Further, we developed a novel strategy of the control of postoperative pain by biodegradable hydrogel and searched biomarkers of postherpetic pain in the cerebrospinal fluid of the patients.
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[Journal Article] The action site of the synthetic kainoid (2S,3R,4R)-3-carboxymethyl-4-(4-methylp henylthio) pyrrolidine-2-carboxylic acid (PSPA-4), an analogue of Japanese mushroom poison acromelic acid, for allodynia (tactile pain)2012
Author(s)
Miyazaki S, Minami T, Mizuma H, Kanazawa, M, Doi H, Matsumura S, Lu J, Onoe H, Furuta K, Suzuki M and Ito S
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Journal Title
Eur J Pharmacol
Volume: (in press)
DOI
Peer Reviewed
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[Presentation] Functional analysis of neuropathic pain- related protein in vivo. 神経障害性疼痛関連分子の同定と機能解析2012
Author(s)
片野泰代, 山崎真弥, 阿部学, 福田正史, 奥村宣明, 中澤敬信, 高尾敏文, 山本雅, 崎村健二, 伊藤誠二
Organizer
第85回日本生化学会大会
Place of Presentation
福岡, 福岡国際 会議場・マリンメッセ福岡
Year and Date
20120214-16
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