2012 Fiscal Year Final Research Report
Investigation of molecular pathology of Down syndrome by high efficient system
| Project/Area Number |
22390078
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
YAMAKAWA Kazuhiro 独立行政法人理化学研究所, 神経遺伝研究チーム, チームリーダー (30241235)
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| Research Collaborator |
下畑 充志 , リサーチアソシエイト
天野 賢治 , 研究員
浅田 幸江 , 研究員
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| Project Period (FY) |
2010 – 2012
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| Keywords | ダウン症 / マウスモデル / 高効率作成 |
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| Research Abstract |
To understand the molecular pathology of Down syndrome, we established a high efficient system in that mouse models with partial trisomy 16 which is syntenic to human chromosome 21. We successfully established 1) Avian cells harboring partial mouse chromosome 16 segments, 2) Mouse ES cells harboring extra partial mouse chromosome 16 derived from the avian cells, and 3) Mice from those ES cells. These resources should greatly contribute to Down syndrome studies.
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