2012 Fiscal Year Final Research Report
Prospective study on the association between metabolic disorders and progress of catotid atherosclerosis in urban general population
| Project/Area Number |
22390138
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
KOKUBO Yoshihiro 独立行政法人国立循環器病研究センター, 病院, 医長 (20393217)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Satoko (独)国立循環器病研究センター, 病院, 医長 (70533008)
KAMIDE Kei 大阪大学, 大学院・医学系研究科, 講師 (80393239)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAMOTO Yoshihiro (独)国立循環器病研究センター, 病院, 部長 (10312224)
WATANABE Makoto (独)国立循環器病研究センター, 病院, 医長 (40343446)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 頚動脈硬化 / 代謝性疾患 / 追跡研究 / 危険因子 / 地域住民 |
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| Research Abstract |
Carotid atherosclerosis was conducted in urban population and examined metabolic disorders and prospective study with the extension of the intimal-medial thickness (IMT) out of the Bichat's tunic from a lifestyle factor. High-normal blood pressure, diabetes, and renal dysfunction were observed significantly increased risk of carotid atherosclerosis. The interaction relationships were observed in between blood pressure category and CRP levels among women, and blood glucose levels. Furthermore, carotid IMT particularly maximal IMT in common carotid artery was found to be a predictor of incident stroke and coronary heart disease by prospective cohort study. High-normal blood pressure, diabetes, non-HDL cholesterol, smoking, and body mass index were found to be the index that was effective for prevention of the arteriosclerosis extension in health guidance.
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Research Products
(39 results)
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[Journal Article] Association of intimamedia thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population.2011
Author(s)
Kamide K, Kokubo Y, Yang J, Takiuchi S, Horio T, Matsumoto S, Banno M, Matayoshi T, Yasuda H, Miwa Y, Yoshihara F, Nakamura S, Nakahama H, Iwashima Y, Oguro R, Ohishi M, Rakugi H, Okamura T, Miyata T, Kawano Y.
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Journal Title
Hypertens Res.
Volume: 34
Pages: 740-746
Peer Reviewed
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[Journal Article] The Combined Impact of Blood Pressure Categories and Glucose Abnormalities on the Incidence of Cardiovascular Diseases in a Japanese Urban Cohort : The Suita Study.2010
Author(s)
Kokubo Y, Okamura T, Watanabe M, Higashiyama A, Ono Y, Miyamoto Y, Furukawa Y, Kamide K, Kawanishi K, Okayama A, Yoshimasa Y
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Journal Title
Hypertens Res.
Volume: 33
Pages: 1238-1243
Peer Reviewed
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