2013 Fiscal Year Final Research Report
Elucidation of the mechanism of cardiac regeneration after transplantation of a complex of cardiac progenitor cells and nanofiber
| Project/Area Number |
22390156
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Chiba University |
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Principal Investigator |
NAGAI TOSHIO 千葉大学, 医学(系)研究科(研究院), 准教授 (00334194)
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| Co-Investigator(Kenkyū-buntansha) |
KOMURO Issei 東京大学, 大学院医学研究科, 教授 (30260483)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | 分子心臓学 / 心臓前駆細胞 / 内在性心筋幹細胞 / 細胞移植 / パラクライン因子 |
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| Research Abstract |
Cardiac cell therapy has been proposed as one of the new strategies against heart failure; however, the mechanisms of the beneficial effects are largely unknown. We found that soluble junctional adhesion molecule-A (JAM-A), which is secreted from transplanted cardiac progenitor cells, prevent cardiac remodeling and reduce fibrosis area after myocardial infarction. In addition, by using a genetic fate-mapping model, we found that both leukemia inhibitory factor and transplantation of cardiac progenitor cells stimulate endogenous cardiomyocyte renewal after myocardial infarction.
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[Journal Article] Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes2012
Author(s)
Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I
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Journal Title
Cell
Volume: 149
Pages: 1298-1313
DOI
Peer Reviewed
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[Journal Article] Urotensin II inhibits the proliferation but not the differentiation of cardiac side population cells2011
Author(s)
Gong H, Ma H, Liu M, Zhou B, Zhang G, Chen Z, Jiang G, Yan Y, Yang C, Kanda M, Wu J, Yuan J, Li L, Nagai T, Komuro I, Ge J, Zou Y
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Journal Title
Peptides
Volume: 32
Pages: 1035-1041
DOI
Peer Reviewed
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[Journal Article] A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure2011
Author(s)
Fukushima N1, Matsuura K, Akazawa H, Honda A, Nagai T, Takahashi T, Seki A, Murasaki KM, Shimizu T, Okano T, Hagiwara N, Komuro I
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Journal Title
PLoS One
Volume: 6(1371/journal.pone.0027901)
Pages: e2790110
Peer Reviewed
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[Journal Article] Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury2010
Author(s)
Naito AT, Okada S, Minamino T, Iwanaga K, Liu ML, Sumida T, Nomura S, Sahara N, Mizoroki T, Takashima A, Akazawa H, Nagai T, Shiojima I, Komuro I
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Journal Title
Circ Res
Volume: 106
Pages: 1692-702
DOI
Peer Reviewed
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[Journal Article] Implantation of cardiac progenitor cells using self-assembling peptide improves cardiac function after myocardial infarction2010
Author(s)
Tokunaga M, Liu ML, Nagai T, Iwanaga K, Matsuura K, Takahashi T, Kanda M, Kondo N, Wang P, Naito AT, Komuro I
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Journal Title
JMol Cell Cardiol
Volume: 49
Pages: 972-983
DOI
Peer Reviewed
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