Investigation of the novel anti-angiogenesis therapy in an orthotopic implantation mouse model of human malignant pleural mesothelioma cells

2012 Fiscal Year Final Research Report

• Project/Area Number: 22390166
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: The University of Tokushima
• Principal Investigator: SONE Saburo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 客員教授 (40145024)
• Co-Investigator(Kenkyū-buntansha): NISHIOKA Yasuhiko 徳島大学, 大学院・ヘスルバイオサイエンス研究部, 教授 (70274199) ; HANIBUCHI Masaki 徳島大学, 大学院・ヘスルバイオサイエンス研究部, 准教授 (80335794) ; KAKIUCHI Soji 徳島大学, 病院, 講師 (50380100) ; GOTO Hisatsugu 徳島大学, 大学院・ヘスルバイオサイエンス研究部, 講師 (00437641)
• Project Period (FY): 2010 – 2012
• Keywords: 非閉塞性肺疾患 / 悪性胸膜中皮腫

Research Abstract

The resistance against anti-VEGF therapy was investigated using orthotopic implantation mouse model of human malignant pleural mesothelioma cells. Although tumor angiogenesis was inhibited in the early phase ofanti-VEGF therapy, microvessel density was turned to increase in the late phase ofthe therapy, suggesting that the tumor acquired the resistance against anti-VEGF therapy. We found that the host FGF2 was up-regulated in the resistant tumor, and anti-FGFR therapy in combination with anti-VEGF therapy was more effective compared to anti-VEGF therapy alone. Angiogenic switch into different factors such as FGF2 seemed to play important role in the resistance against anti-VEGF therapy.

Research Products

• [Journal Article] Macrophage stimulating protein promotes liver metastases of small cell lung cancer cells by affecting the organ microenvironme (2013)
  • Author(s): Sato S, Hanibuchi M, Kuramoto T, Yamamori N, Goto H, Ogawa H, Mitsuhashi A, Van TT, Kakiuchi S, Akiyama SI, Nishioka Y, Sone S
  • Journal Title: Clin Exp Metastasis Volume: 30 Pages: 333-344
  • DOI: DOI:10.1007/s10585-012-9540-y
  • Peer Reviewed
• [Journal Article] imeric anti-podoplanin antibody suppresses tumor metastasis through neutralization and antibody-dependent cellular cytotoxicity (2013)
  • Author(s): Kaneko MK, Kunita A, Abe S, Tsujimoto Y, Fukayama M, Goto K, Sawa Y, Nishioka Y, Kato Y
  • Journal Title: Cancer Sci Volume: 103 Pages: 1913-1919
  • DOI: DOI:10.1111/j.1349-7006.2012.02385.x
  • Peer Reviewed
• [Journal Article] an inhibitor of Dll4-Notch signaling, suppresses liver metastasis of small cell lung cancer cells through the downregulation of the NF-kappa-B activity (2012)
  • Author(s): Kuramoto T, Goto H, Mitsuhashi A, Tabata S, Ogawa H, Uehara H, Saijo A, Kakiuchi S, Maekawa Y, Yasutomo K, Hanibuchi M, Akiyama SI, Sone S, Nishioka Y
  • Journal Title: Mol Cancer Ther Volume: 11 Pages: 2578-2587
  • DOI: DOI:10.1158/1535-7163.MCT-12-0640
  • Peer Reviewed
• [Journal Article] Malignant pleural effusion: further translational research is crucia (2012)
  • Author(s): Nishioka Y
  • Journal Title: Transl Lung Cancer Res Volume: 1 Pages: 167-169
  • DOI: DOI:10.1111/j.1349-7006.2012.02385.x.
  • Peer Reviewed
• [Journal Article] Akiyama S, Thymidine phosphorylase enhances reactive oxygen species generation and interleukin-8 expression in human cancer cells (2012)
  • Author(s): Tabata S, Ikeda R, Yamamoto M, Furukawa T, Kuramoto T, Takeda Y, Yamada K, Haraguchi M, Nishioka Y, Sone S
  • Journal Title: Oncol Rep Volume: 28 Pages: 895-902
  • DOI: DOI:10.3892/or.2012.1887.
  • Peer Reviewed
• [Journal Article] Dual inhibition of met kinase and angiogenesis to overcome HGF-induced EGFR-TKI resistance in EGFR mutant lung cancer (2012)
  • Author(s): Takeuchi S, Wang W, Li Q, Yamada T, Kita K, Donev IS, Nakamura T, Matsumoto K, Shimizu E, Nishioka Y, Sone S, Nakagawa T, Uenaka T, Yano
  • Journal Title: Am J Pathol Volume: 181 Pages: 1034-1043
  • DOI: DOI:10.1016/j.ajpath.2012.05.023.
  • Peer Reviewed
• [Journal Article] a multiple tyrosine kinase inhibitor, inhibits progression of human malignant pleural mesothelioma in an orthotopic model (2012)
  • Author(s): Van TT, Hanibuchi M, Goto H, Kuramoto T, Yukishige S, Kakiuchi S, Sato S, Sakaguchi S, Dat LT, Nishioka Y, Akiyama SI, Sone S, SU666
  • Journal Title: Respirology Volume: 17 Pages: 984-990
  • DOI: DOI:10.1111/j.1440-1843.2012.02193.x.
  • Peer Reviewed
• [Journal Article] 呼吸器疾患におけるトランスレーショナルリサーチ:現状と将来展望 (2012)
  • Author(s): 西岡安彦, 曽根三郎
  • Journal Title: 呼吸器内科 Volume: 21 Pages: 483-484
  • URL: http://www.kahyo.com/item/KO201206-216
  • Peer Reviewed
• [Journal Article] Identification of genes potentially involved in bone metastasis by genome-wide gene expression profile nalysis of non-small cell lung cancer in mic (2012)
  • Author(s): Dat LT, Matsuo T, Yoshimaru T, Kakiuchi S, Goto H, Hanibuchi M, Kuramoto T, Nishioka Y, Sone S, Katagiri T
  • Journal Title: Int J Oncol Volume: 40 Pages: 1455-1469
  • DOI: DOI:10.3892/ijo.2012.1348
  • Peer Reviewed
• [Journal Article] Erlotinib prevents experimental metastases of human small cell lung cancer cells with no epidermal growth factor receptor expression (2012)
  • Author(s): abr AG, Goto H, Hanibuchi M, Ogawa H, Kuramoto T, Suzuki M, Saijo A, Kakiuchi S, Trung VT, Sakaguchi S, Mori
  • Journal Title: Clin Exp Metastasis Volume: 29 Pages: 207-216
  • DOI: DOI:10.1007/s10585-011-9443-3.
  • Peer Reviewed
• [Journal Article] Met kinase inhibitor E7050 reverses three different mechanisms of hepatocyte growth factor-induced tyrosine kinase inhibitor resistance in EGFR mutant lung cance (2012)
  • Author(s): Wang W, Li Q, Takeuchi S, Yamada T, Koizumi H, Nakamura T, Matsumoto K, Mukaida N, Nishioka Y, Sone S, Nakagawa T, Uenaka T, Yano S
  • Journal Title: Clin Cancer Res Volume: 18 Pages: 1663-1671
  • DOI: DOI:10.1158/1078-0432.CCR-11-1171.
  • Peer Reviewed
• [Journal Article] Genetically engineered humanized anti-ganglioside GM2 antibody against multiple organ metastasis produced by GM2-expressing small-cell lung cancer cells (2011)
  • Author(s): Yamada T, Bando H, Takeuchi S, Kita K, Li Q, Wang W, Akinaga S, Nishioka Y, Sone S, Yano S
  • Journal Title: Cancer Sci Volume: 102 Pages: 2157-2163
  • DOI: DOI:10.1111/j.1349-7006.2011.02093.x.
  • Peer Reviewed
• [Journal Article] Pleural mesothelioma instigates tumor- associated fibroblasts to promote progression via a malignant cytokine network (2011)
  • Author(s): Li Q, Wang W, Yamada T, Matsumoto K, Sakai K, Bando Y, Uehara H, Nishioka Y, Sone S, Iwakiri S, Itoi K, Utsugi T, Yasumoto K, Yano S
  • Journal Title: Am J Pathol Volume: 179 Pages: 1483-1493
  • DOI: DOI:10.1016/j.ajpath.2011.05.060.
  • Peer Reviewed
• [Journal Article] The therapeutic efficacy of S-1 against orthotopically implanted human pleural mesothelioma cells in severe combined immunodeficient mice (2011)
  • Author(s): Van TT, Hanibuchi M, Kakiuchi S, Sato S, Kuramoto T, Goto H, Mitsuhashi A, Nishioka Y, Akiyama S, Sone S
  • Journal Title: Cancer Chemother Pharmacol Volume: 68 Pages: 497-504
  • DOI: DOI:10.1007/s00280-010-1503-x
  • Peer Reviewed
• [Journal Article] E7080 suppresses hematogenous multiple organ metastases of lung cancer cells with nonmutated epidermal growth factor recepto (2011)
  • Author(s): Ogino H, Hanibuchi M, Kakiuchi S, Trung VT, Goto H, Ikuta K, Yamada T, Uehara H, Tsuruoka A, Uenaka T, Wang W, Li Q, Takeuchi S, Yano S, Nishioka Y, Sone S
  • Journal Title: Mol Cancer The Volume: 10 Pages: 1218-1228
  • DOI: DOI:10.1158/1535-7163.MCT-10-0707.
  • Peer Reviewed
• [Journal Article] Role of tyrosine kinase inhibitors in tumor immunology (2011)
  • Author(s): Nishioka Y, Aono Y, Sone S
  • Journal Title: Immunotherapy Volume: 3 Pages: 107-116
  • DOI: DOI:10.2217/imt.10.79
  • Peer Reviewed
• [Journal Article] ntiangiogenic therapies for malignant pleural mesothelioma (2011)
  • Author(s): Yano S, Li Q, Wang W, Yamada T, Takeuchi S, Nakataki E, Ogino H, Goto H, Nishioka Y, Sone S
  • Journal Title: Front Biosci Volume: 16 Pages: 740-748
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21196199.
• [Journal Article] Gender difference in bone metastasis of human small cell lung cancer, SBC-5 cells in natural killer-cell depleted severe combined immunodeficient mice (2010)
  • Author(s): Sakaguchi S, Goto H, Hanibuchi M, Otsuka S, Ogino H, Kakiuchi S, Uehara H, Yano S, Nishioka Y, Sone, S
  • Journal Title: Clin Exp Metastasis Volume: 27 Pages: 351-359
  • DOI: DOI:10.1007/s10585-010-9333-0
  • Peer Reviewed
• [Book] 学研メディカル秀潤社、がん転移:臨床と研究の羅針盤 (2010)
  • Author(s): 曽根三郎
  • Total Pages: 58-62
• [Book] 疾患と治療薬改訂第6版-医師・薬剤師の為のマニュアル (2010)
  • Author(s): 曽根三郎
  • Total Pages: 132-136
  • Publisher: 南江堂
• [Book] 今日の診断指針第6 版 (2010)
  • Author(s): 曽根三郎
  • Total Pages: 315-322
  • Publisher: 医学書院
• [Book] 呼吸器疾患最新の治療 (2010)
  • Author(s): 矢野聖二
  • Total Pages: 432-434
  • Publisher: 南江堂