2013 Fiscal Year Final Research Report
Analysis of novel molecule in aging and metabolism toward translational research
| Project/Area Number |
22390186
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Osaka University |
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Principal Investigator |
NAKAGAMI Hironori 大阪大学, 連合小児発達学研究科, 寄附講座教授 (20325369)
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| Co-Investigator(Kenkyū-buntansha) |
RAKUGI Hiromi 大阪大学, 医学(系)研究科(研究院), 教授 (20252679)
KATSUYA Tomohiro 大阪大学, 医学(系)研究科(研究院), その他 (30311757)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 糖代謝 / インスリン抵抗性 / アルファシヌクレイン |
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| Research Abstract |
Here we show the function of alpha-synuclein(SNCA) in the glucose metabolism, which is a susceptible gene for Parkinson disease. In a transversal study in Japanese population, we found that serum SNCA was strongly inversely correlated with elevated seric insulin resistance indicators. Additionally, in SNCA knock-out mice only glucose metabolism is impaired in glucose and insulin response during dietary-induced insulin resistance. In vitro, treatment of recombinant SNCA activates PI3K/Akt pathway through Gab1 activation, independently of insulin receptor activation, leading to glucose uptake in 3T3-L1 cells. Also in vivo, injection of SNCA activates Gab1-Akt-glucose uptake pathway in adipose tissue and muscle thereby promoting glucose utilization in mice. Moreover, during insulin resistance, SNCA treatment decreased blood glucose levels thus recovering glucose utilization in tissues. These findings suggest serum SNCA potential for prevention or treatment against insulin resistance.
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[Journal Article] Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway2013
Author(s)
Rodriguez-Araujo G, Nakagami H, Hayashi H, Mori M, Shiuchi T, Minokoshi Y, Nakaoka Y, Takami Y, Komuro I, Morishita R, Kaneda Y
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Journal Title
Cell Mol Life Sci
Volume: 70(6)
Pages: 1123-33
Peer Reviewed
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