2012 Fiscal Year Final Research Report
Elucidation and regulation of mast cell activation by FcεRIβ chain
| Project/Area Number |
22390202
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Nihon University |
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Principal Investigator |
RA Chisei 日本大学, 医学部, 教授 (60230851)
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| Co-Investigator(Kenkyū-buntansha) |
OKAYAMA Yoshimichi 日本大学, 医学部, 准教授 (80292605)
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| Co-Investigator(Renkei-kenkyūsha) |
NUNOMURA Satoshi 日本大学, 医学部, 助教 (70424728)
SHIMOKAWA Toshibumi 日本大学, 医学部, 助教 (10339327)
SUZUKI Yoshihiro 日本大学, 医学部, 助教 (80206549)
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| Project Period (FY) |
2010 – 2012
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| Keywords | アレルギー / マスト細胞 / シグナル伝達 |
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| Research Abstract |
The β chain, a signaling molecule for the high-affinity IgE receptor (FcεRI), is involved in FcεRI-induced mast cell activation. In the present study, we investigated employing human and/or murine mast cells how the β chain regulates FcεRI signaling and mast cell activation. Here, we demonstrated that, upon weak Fc ε RI ligation, β chain amplifies human mast cell activation by increasing positive function of Lyn.
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[Journal Article] Activation of human synovial mast cells from rheumatoid arthritis or osteoarthritis patients in response to aggregated IgG through Fcγ receptor I and Fcγ receptor II.2013
Author(s)
Lee H, Kashiwakura J, Matsuda A, Watanabe Y, Sakamoto-Sasaki T, Matsumoto K, Hashimoto N, Saito S, Ohmori K, Nagaoka M, Tokuhashi Y, Ra C, Okayama Y.
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Journal Title
Arthritis Rheum.
Volume: 65(1)
Pages: 109-19
DOI
Peer Reviewed
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[Journal Article] The interaction between Lyn and FcεRIβ is indispensable for FcεRI-mediated human mast cell activation.2012
Author(s)
Okayama Y, Kashiwakura JI, Matsuda A, Sasaki-Sakamoto T, Nunomura S, Yokoi N, Ebihara N, Kuroda K, Ohmori K, Saito H, Ra C.
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Journal Title
Allergy.
Volume: 67(10)
Pages: 1241-9
DOI
Peer Reviewed
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