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2012 Fiscal Year Final Research Report

Molecular mechanisms underlying development and interaction of progenitor cells essential for cardiac outflow tract morphogenesis

Research Project

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Project/Area Number 22390211
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKeio University

Principal Investigator

YAMAGISHI Hiroyuki  慶應義塾大学, 医学部, 講師 (40255500)

Co-Investigator(Kenkyū-buntansha) UCHIDA Keiko  慶應義塾大学, 医学部, 共同研究員 (50286522)
YAMAGISHI Chihiro  慶應義塾大学, 医学部, 共同研究員 (10296618)
TSUCHIHASHI Takatoshi  慶應義塾大学, 医学部, 共同研究員 (10286528)
KODO Kazuki  慶應義塾大学, 医学部, 助教 (10338105)
MAKINO Shinji  慶應義塾大学, 医学部, 特任准教授 (20306707)
YUASA Shinsuke  慶應義塾大学, 医学部, 講師 (90398628)
Project Period (FY) 2010 – 2012
Keywords小児循環器学
Research Abstract

Two progenitor cell lineages, the cardiac neural crest cells (cNCCs) and the second heart field (SHF), play key roles in development of the cardiac outflow tract (OFT), and their interaction is essential for establishment of completely separated pulmonary

  • Research Products

    (29 results)

All 2012 2011 2010

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (21 results)

  • [Journal Article] Factors involved in signal transduction during vertebrate myogenesis2012

    • Author(s)
      Takagaki Y, Yamagishi H, Matsuoka R
    • Journal Title

      International Review of Molecular Biology

      Volume: 296 Pages: 187-272.

  • [Journal Article] Genetic analysis of essential cardiac transcription factors in 256 patients with non-syndromic congenital heart defects2012

    • Author(s)
      Kodo K, Nishizawa T, Furutani M, Arai S, Ishihara K, Oda M, Makino S, FukudaK, Takahashi T, Matsuoka R, Nakanishi T, Yamagishi H.
    • Journal Title

      Circ J

      Volume: 76(7) Pages: 1703-1711.

    • Peer Reviewed
  • [Journal Article] The impact of cardiac surgery in patients with trisomy 18 and trisomy 13 in Japan2011

    • Author(s)
      Maeda J, Yamagishi H, Furutani Y, Kamisago M, Waragai T, Oana S, Kajino H, Matsuura H, Mori K, Matsuoka R, Nakanishi T
    • Journal Title

      Am J Med Genet A

      Volume: 155A(11) Pages: 2641-2646.

    • Peer Reviewed
  • [Journal Article] Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field2011

    • Author(s)
      Nakazawa M, Uchida K, Aramaki M, Kodo K, Yamagishi C, Takahashi T, Mikoshiba K, Yamagishi H
    • Journal Title

      J Mol Cell Cardiol

      Volume: 51 Pages: 58-66

    • Peer Reviewed
  • [Journal Article] Hand2 function in second heart field progenitors is essential for cardiogenesis2011

    • Author(s)
      Tsuchihashi T, Maeda J, Shin CH, Ivey KN, Black BL, Olson EN, Yamagishi H, Srivastava D
    • Journal Title

      Dev Biol

      Volume: 351 Pages: 62-69

    • Peer Reviewed
  • [Journal Article] The antiproliferative action of progesterone in uterine epithelium is mediated by Hand22011

    • Author(s)
      Li Q, Kannan A, DeMayo FJ, Lydon JP, Cooke PS, Yamagishi H, Srivastava D, Bagchi MK, Bagchi IC
    • Journal Title

      Science

      Volume: 331 Pages: 912-916

    • Peer Reviewed
  • [Journal Article] Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis2010

    • Author(s)
      Uchida K, Aramaki M, Nakazawa M, Yamagishi C, Makino S, Fukuda K, Nakamura T, Takahashi T, Mikoshiba K, Yamagishi H
    • Journal Title

      PLoS One

      Volume: 5(9) Pages: e12500

    • Peer Reviewed
  • [Journal Article] Mechanisms underlying early development of pulmonary vascular obstructive disease in Down syndrome: An imbalance in biosynthesis of thromboxane A2 and prostacyclin2010

    • Author(s)
      Fukushima H, Kosaki K, Sato R, Yagihashi T, Gatayama R, Kodo K, Hayashi T, Nakazawa M, Tsuchihashi T, Maeda J, Kojima Y, Yamagishi H, Takahashi T
    • Journal Title

      Am J Med Genet A

      Volume: 152A Pages: 1919-1924

    • Peer Reviewed
  • [Presentation] 小児循環器医のための発生学と臨床遺伝2012

    • Author(s)
      山岸敬幸
    • Organizer
      第7回愛媛発達心臓病研究会
    • Place of Presentation
      松山
    • Year and Date
      2012-12-01
  • [Presentation] 先天性心疾患の心エコー図に役立てたい臨床心臓発生学2012

    • Author(s)
      山岸敬幸
    • Organizer
      第52回東京心エコー図研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-24
  • [Presentation] 胎児心スクリーニングに役立つ発生学の知識2012

    • Author(s)
      山岸敬幸
    • Organizer
      第50回神奈川胎児エコー研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-13
  • [Presentation] 先天性心疾患を科学する 臨床心臓発生学のスゝメ2012

    • Author(s)
      山岸敬幸
    • Organizer
      日本小児科学会栃木県地方会
    • Place of Presentation
      宇都宮
    • Year and Date
      2012-07-14
  • [Presentation] 基礎・心臓の発生 房室中隔の発生2012

    • Author(s)
      山岸敬幸
    • Organizer
      第48回日本小児循環器学会学術集会・教育セッション
    • Place of Presentation
      京都
    • Year and Date
      2012-07-07
  • [Presentation] 先天性心疾患の発症分子機構解明と臨床心臓発生学の発展2012

    • Author(s)
      山岸敬幸
    • Organizer
      第48回日本小児循環器学会『高尾賞』受賞記念講演
    • Place of Presentation
      京都
    • Year and Date
      2012-07-06
  • [Presentation] 成人先天性心疾患の基礎知識・先天性心疾患と遺伝2012

    • Author(s)
      山岸敬幸
    • Organizer
      第6回成人先天性心疾患セミナー
    • Place of Presentation
      東京
    • Year and Date
      2012-06-09
  • [Presentation] 臨床心臓発生学の進歩2012

    • Author(s)
      山岸敬幸
    • Organizer
      第21回京都小児循環器病カンファレンス
    • Place of Presentation
      京都
    • Year and Date
      2012-06-02
  • [Presentation] 世界に発信する小児循環器の基礎研究 -臨床心臓発生学のすゝめ-2012

    • Author(s)
      山岸敬幸
    • Organizer
      The 6th CSR Research Seminar
    • Place of Presentation
      奈良
    • Year and Date
      2012-02-10
  • [Presentation] 先天性心疾患診療のための発生学・遺伝学の基本と新たな流れ2011

    • Author(s)
      山岸敬幸
    • Organizer
      第5回鹿児島小児循環器研究会学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2011-08-27
  • [Presentation] 世界をリードする臨床心臓発生学研究2011

    • Author(s)
      山岸敬幸
    • Organizer
      第94回慈恵医大小児医学研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-07-16
  • [Presentation] 基礎発生・神経堤細胞と先天性心疾患2011

    • Author(s)
      山岸敬幸
    • Organizer
      第47回日本小児循環器学会・教育セッション
    • Place of Presentation
      福岡
    • Year and Date
      2011-07-08
  • [Presentation] 先天性心疾患の遺伝子研究2011

    • Author(s)
      山岸敬幸
    • Organizer
      第73回東京心臓の会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-11
  • [Presentation] 成人先天性心疾患の診療に必要な遺伝の知識2011

    • Author(s)
      山岸敬幸
    • Organizer
      第4回成人先天性心疾患セミナー
    • Place of Presentation
      東京
    • Year and Date
      2011-05-14
  • [Presentation] Developmental origins of syndromic and non-syndromic cardiac outflow tract defects2011

    • Author(s)
      Yamagishi H
    • Organizer
      Pediatric Academic Society (PAS/ASPR) 2011・Topic symposium: Molecular Pathogenesis of Cardiovascular Diseases of Childhood
    • Place of Presentation
      Denver, USA
    • Year and Date
      2011-05-01
  • [Presentation] 先天性心疾患成因にアプローチするための臨床心臓発生学2011

    • Author(s)
      山岸敬幸
    • Organizer
      第49回山梨小児循環器懇話会
    • Place of Presentation
      山梨
    • Year and Date
      2011-03-04
  • [Presentation] 先天性心疾患の成因と遺伝カウンセリング2010

    • Author(s)
      山岸敬幸
    • Organizer
      第187回大阪小児科学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-26
  • [Presentation] 心室中隔欠損の臨床と発生2010

    • Author(s)
      山岸敬幸
    • Organizer
      第9回心臓血管発生研究会・教育セッション
    • Place of Presentation
      郡山
    • Year and Date
      2010-07-10
  • [Presentation] Cardiovascular morphogenesis and development of the systemic and pulmonary circulation.2010

    • Author(s)
      Yamagishi H
    • Organizer
      The 7th Scientific Symposium
    • Place of Presentation
      東京
    • Year and Date
      2010-07-04
  • [Presentation] こどもの心臓病のために学ぶ、発生と遺伝の初歩2010

    • Author(s)
      山岸敬幸
    • Organizer
      第113回日本小児科学会学術集会・教育セミナー
    • Place of Presentation
      岩手
    • Year and Date
      2010-04-23
  • [Presentation] 先天性心疾患の分子遺伝学的解明2010

    • Author(s)
      山岸敬幸
    • Organizer
      第113回日本小児科学会学術集・分野別シンポジウム
    • Place of Presentation
      岩手
    • Year and Date
      2010-04-23

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Published: 2014-08-29  

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