2012 Fiscal Year Final Research Report
Elucidation of Molecular Mechanism of Cell Death induced by Radiation, Hyperthermia and Ultrasound for Cancer Therapy
Project/Area Number |
22390229
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | University of Toyama |
Principal Investigator |
KONDO Takashi 富山大学, 大学院・医学薬学研究部(医学), 教授 (40143937)
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Co-Investigator(Kenkyū-buntansha) |
TABUCHI Yoshiaki 富山大学, 生命科学先端研究センター, 准教授 (20322109)
ZHAO Qing-li 富山大学, 大学院・医学薬学研究部(医学), 助教 (90313593)
TAKASAKI Ichro 富山大学, 生命科学先端研究センター, 助教 (00397176)
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Project Period (FY) |
2010 – 2012
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Keywords | 放射線腫瘍学 / 超音波治療学 / 温熱治療学 |
Research Abstract |
Molecular mechanism of cell death induced by ionizing radiation, heat or ultrasound was examined. Stable knockdown of TAK1 caused increase in subG1 fraction and apoptosis induced by X-rays in HeLa cells. Inhibition of DNA-PK increased heat-induced apoptosis in HeLa cells and the knockdown of an identified gene, NR1D1, also enhanced apoptosis. For the cell death induced by ultrasound, cell death signal is modulated by the balance between p53 and Akt via ATM and DNA-PK and the pathway of DNA-PK/Akt is predominant in sonicated cells.
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Research Products
(18 results)
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[Journal Article] TGF-beta-activated kinase 1 promotes cell cycle arrest and cell survival of X-ray-irradiated HeLa cells dependent on p21 induction but independent of NF-kB, p38 MAPK and ERK phosphorylations2012
Author(s)
Furusawa Y, Wei ZL, Sakurai H, Tabuchi Y, Li P, Zhao Q-L, Zhao, Nomura T, Saiki I, and Kondo T
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Journal Title
Radiat Res
Volume: 177
Pages: 766-774
DOI
Peer Reviewed
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[Journal Article] Mitochondoria -targeted superoxide dismutase (SOD2) regulates radiation resitance and radiation stress response in HeLa cells2012
Author(s)
Hosoki A., Yonekura S.-I., Zhao Q.-L., Wei Z.-L., Takasaki I., Tabuchi Y., Wang L.-L., Hasuike S., Nomura T., Tchibana A., Hashiguchi K., Yonei S., Kondo T., and Zhang-Akiyama Q.-M
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Journal Title
J Radiat Res
Volume: 53
Pages: 58-71
DOI
Peer Reviewed
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[Book] Ultrasound-induced DNA damage and signal transductions indicated by gamma H2AX2011
Author(s)
Furusawa Y, Fijiwara Y, Zhao Q-L, Hassan MA, Ogawa R, Tabuchi Y, Takasaki I,Takahashi A, Ohnishi T, and Kondo T
Publisher
10th International Symposium on Therapeutic Ultrasound (ISTU2010) Editors, Matsumoto Y, Crum LA, and ter Haar GR, 322-325, AIP Conf Proc 1359, American Institute of Physics
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