2012 Fiscal Year Final Research Report
Elucidation of mechanisms for responses of normal tissues exposedto low dose radiation in the radiation cancer therapy
| Project/Area Number |
22390231
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Fukui |
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Principal Investigator |
MATSUMOTO Hideki 福井大学, 高エネルギー医学研究センター, 准教授 (40142377)
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| Co-Investigator(Kenkyū-buntansha) |
KITAI Ryuhei 福井大学, 医学部附属病院, 講師 (80251990)
NARITA Norihiko 福井大学, 医学部, 助教 (80345678)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 放射線治療生物学 |
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| Research Abstract |
To elucidate mechanisms for responses of normal tissues exposed to low dose radiation, the induction of apoptosis in the small intestine and testis from whole body-irradiated ICR mice (Jcl:ICR, 5 weeks old, male) with carbon ion beams at 0.01 ~ 2.0 Gy. The apoptosis was specifically induced in the intestinal crypts and the outermost region of lobuli testisin the mice irradiated at 2.0 Gy. In addition, the apoptosis was detected in the intestine and testis from the mice irradiated at 0.01 ~ 0.05 Gy in the same manner. The incidence of apoptotic cells in the intestine increased in the dose-dependent manner. Finally, the immunehistochemical analysis indicated that the apoptotic cells induced in the intestine or testis were the tissue or germ stem cells and their progenitor cells, respectively.
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Research Products
(38 results)
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[Journal Article] Ionizing Radiation Leads to the Replacement and de novo Production of Colonic Lgr5^+Stem Cells.2012
Author(s)
Otsuka, K., Hamada, N., Magae, J., Matsumoto, H., Hoshi, Y., Iwasaki, T
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Journal Title
Radiat. Res
Volume: (In press)
Peer Reviewed
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[Journal Article] The combination of olaparib and camptothecin for effective radiosensitization2012
Author(s)
Miura, K., Sakata, K., Someya, M., Matsumoto, Y., Matsumoto, H., Takahashi, A., Hareyama, M
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Journal Title
Radiat. Oncol
Volume: 7
Pages: 62
Peer Reviewed
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[Journal Article] Suppression of histone deacetylase 3 (HDAC3) enhances apoptosis induced by paclitaxel in human maxillary cancer cells in vitro and in vivo2010
Author(s)
Narita, N., Fujieda, S., Kimura, Y., Ito, Y., Imoto, Y., Ogi, K., Takahashi, N., Tanaka, T., Tsuzuki, H., Yamada, T., Matsumoto, H
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 396
Pages: 310-316
Peer Reviewed
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[Presentation] 放射線誘発バイスタンダー応答による放射線適応応答の誘導2012
Author(s)
松本英樹, 畑下昌範, 前田宗利, 冨田雅典, 大塚健介, 舟山知夫, 横田裕一郎, 武藤泰子, 鈴木芳代, 坂下哲哉, 小林泰彦
Organizer
第7回高崎量子応用研究シンポジウム
Place of Presentation
高崎市
Year and Date
2012-10-12
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[Presentation] Nitric oxide is a key molecule serving as a bridge between radiation-induced bystander and adaptive responses2011
Author(s)
Matsumoto, H., Tomita, M., Otsuka, K., Maeda, M., Hamada, N., Hatashita, M
Organizer
14th International Congress of Radiation Research
Place of Presentation
Warsaw (Poland)
Year and Date
2011-08-30
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