2012 Fiscal Year Final Research Report
Establishment of novel living tissue adhesion method by using integrated low-level energies of heat, pressure and vibration
| Project/Area Number |
22390242
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Ibaraki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIGAMI Tetsuya 札幌医科大学, 医学部, 教授 (60335429)
KISHIDA Akio 東京医科歯科大学, 生体材料工学研究所, 教授 (60224929)
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| Co-Investigator(Renkei-kenkyūsha) |
OZEKI Kazuhide 茨城大学, 工学部, 准教授 (20366404)
KIMURA Tsuyoshi 東京医科歯科大学, 生体材料工学研究所, 助教 (10393216)
KATOH Ayako 埼玉医科大学, 保健医療学部, 講師 (30318159)
TOSHIYUKI Aodai 松江工業高等専門学校, 電子制御工学科, 助教 (40571849)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 人工臓器学 / 手術機器 / 生体組織結合 / 生体組織接着 |
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| Research Abstract |
Novel biological tissue adhesion method, which is using integrated low-level energy sources of heat, vibration and pressure, has been established. Morphological changes of collagen by heating and applying pressure were observed. It seems that thermal cross-links of collagen fibers could contribute the adhesion strength. We succeeded in shortening the adhesion time to 20 sec by developing specialized heater control unit. The adhesion performance with metal specimen can be regulated by using DLC coating and changing the roughness of metal surface. The polymer material with polar groups can be adhered on the living tissue. In animal experiments, no inflammation was observed, the tissue construction could be preserved well and the adhesion performance could be kept for more than 1 month in the living body.
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[Journal Article] Synthetic polymer?tissue adhesion using an ultrasonic scalpel2011
Author(s)
Yamamoto K,Kimura T,Kwangwoo Nam,Funamoto S,Ito Y,Shiba K,Ayako Katoh,Shimizu S,Kurita K,Higami T,Masuzawa T,Kishida A
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Journal Title
Surgical Endoscopy
Volume: 25巻
Pages: 1270-1275
Peer Reviewed
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