2013 Fiscal Year Final Research Report
Establishment of specific cancer vaccination therapy for pancreatic and biliary cancer.
| Project/Area Number |
22390253
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
EGAWA Shinichi 東北大学, 災害科学国際研究所, 教授 (00270679)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Hiroki 東北大学, 病院, 助教 (30422124)
SAKATA Naoaki 東北大学, 病院, 助教 (50431565)
OKADA Takaho 東北大学, 病院, 助教 (10375074)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | ペプチドワクチン / 膵癌 / 胆道癌 / 腫瘍関連抗原 / WT1 / プロテオミクス |
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| Research Abstract |
Pancreatic and biliary cancer is still poor prognostic cancer though surgical, chemotherapeutic and radiological treatment is improving. In this research, we vaccinated the highest rank tumor associated antigen WT1 peptide to patients with chemo-refractory pancreatic cancer. Median survival rate of the patients was eight month in a certain condition resulting in the prospective randomized trial. We confirmed that pancreatic adenocarcinoma, neuroendocrine tumors and acinar cell carcinoma expressed WT1 frequently. We also found new molecular targets relevant to the prognosis from the resected specimen.
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