Establishment a therapeutic strategy to children with heart failure

2014 Fiscal Year Final Research Report

• Project/Area Number: 22390271
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Keio University
• Principal Investigator: AEBA Ryo 慶應義塾大学, 医学部, 准教授 (70184025)
• Co-Investigator(Kenkyū-buntansha): YOZU Ryohei 慶應義塾大学, 医学部, 講師 (30129738) ; UMEZAWA Akihiro 国立成育医療研究センター研究所, 再生医療センター長 (70213486)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 重症心不全 / 細胞治療 / 細胞バンキング / 人工心臓 / 細胞培養

Outline of Final Research Achievements

It is quite important to accumulate scientific data, promote science-based industrial development and harmonize regulatory issues for cell-based therapy in pediatric cardiology. However, heart transplantation, artificial device, and cell-based therapy have been applied to adult patients with severe heart failure, but not to pediatric patients. In this study, we aim to establish a therapeutic strategy to children with heart failure, and provide the important areas of cell-based therapy with somatic cells such as skeletal myocytes and cardiomyocytes under both the Medical affairs law and Pharmaceutical affairs law. This study addresses critical issues in the field, exchanges new ideas and disseminates the latest developments in basic research and clinical translation focusing on cell-based therapy to patients with heart failure.

Free Research Field

心臓血管外科