2012 Fiscal Year Final Research Report
Development of an acellular cartilage tissue engineering technique using an ultra-purified in-situ forming gel
| Project/Area Number |
22390285
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KASAHARA Yasuhiko 北海道大学, 病院・整形外科, 助教 (00581927)
HUNAKOSHI Tadanao 北海道大学, 病院・整形外科, 講師 (10528334)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 軟骨再生 / SDF-1 / 無細胞治療 / ウサギ / 骨髄間葉幹細胞 |
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| Research Abstract |
We succeeded in achieving hyaline-like cartilage repair by local administration of SDF-1 using an ultra-purified in-situ forming (UPIF) gel without cells. The obtained results indicate that UPIF gel enhances chondrogenesis of bone marrow stromal cells recruited by the chemotactic effect of SDF-1, leading to a novel cell-free approach for cartilage tissue engineering.
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