2013 Fiscal Year Final Research Report
Development of novel cell-penetrating peptides for treatment of cancer pain
| Project/Area Number |
22390297
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Hyogo Medical University (2012-2013)
University of Fukui (2010-2011) |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | がん性疼痛 / 細胞膜透過性ペプチド / 神経成長因子 / 鎮痛薬 / 疼痛管理学 / TrkA |
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| Research Abstract |
TrkA, a protein locating at neuron or malignant cells, is known to have a relation to pain and proliferation of cancer cells. My previous studies revealed that IPTRK3, a novel inhibitor of TrkA activity which I developed, suppresses pain in rodents. In this study, I synthesized 4 more peptides (IPTRK4, IPTRK5, IPTRK6, IPTRK7) and examined their effect on TrkA activity, followed by the investigation of their effect on either proliferation of cancer cell or cancer pain in rodents. Both IPTRK3 and IPTRK5 showed antiproliferative effect on cancer together with suppressive effect on cancer pain.
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Research Products
(30 results)
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[Journal Article] Oligopeptides derived from autophosphorylation sites of EGF receptor suppress EGF-stimulated responses in human lung carcinoma A549 cells2013
Author(s)
Kuroda Y, Kato-Kogoe N, Tasaki E, Murata M, Ueda K, Abe M, Miyamoto K, Nakase I, Futaki S, Tohyama Y, Hirose M
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Journal Title
Eur J Pharmacol
Volume: 698
Pages: 87-94
Peer Reviewed
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