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2012 Fiscal Year Final Research Report

Development of new anticancer drugs and nanobubbles suitable for specific molecular target therapy using sonoporation

Research Project

  • PDF
Project/Area Number 22390389
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKyushu Dental College

Principal Investigator

FUKUDA Jinichi  九州歯科大学, 歯学部, その他 (00106270)

Co-Investigator(Kenkyū-buntansha) IWANAGA Kenjiro  九州歯科大学, 歯学部, 助教 (20448484)
TOMINAGA Kazuhiro  九州歯科大学, 歯学部, 教授 (40188793)
NISHIHARA Tatsuji  九州歯科大学, 歯学部, 教授 (80192251)
HABU Manabu  九州歯科大学, 歯学部, 助教 (00360058)
KODAMA Masaaki  九州歯科大学, 歯学部, 助教 (40423975)
Co-Investigator(Renkei-kenkyūsha) NISHINO Norikazu  九州工業大学, 生命体工学研究科, 教授 (40145165)
Project Period (FY) 2010 – 2012
Keywordsソノポレーション / ナノバブル / 癌
Research Abstract

We investigated the effects on cytotoxicity by combination of a novel HDAC inhibitor, Ky-2, and bubble liposomes on oral squamous carcinoma cells in vitro. Cell viability was significantly reduced by treatment with Ky-2 at 25 nM and bubble liposomes and ultrasoud, while it also led to augmentation of the proportion of cells in the sub-G1 phase and DNA fragmentation. In addition, immunoblot analysis revealed that Ky-2 enhanced the expression of apoptosis-related proteins. We made new bubble liposomes from Doxil(R) and investigated the effects on cytotoxicity by combination of this new Doxil(R) bubble liposome (encapsulated doxorubicin bubble liposomes, EDBL) and ultrasound in human gingival squamous cell carcinoma Ca9-22 cells. Results showed that the effect on cytotoxity was enhanced by a combination of EDBL and ultrasound.

  • Research Products

    (8 results)

All 2013 2012 2011

All Journal Article (4 results) Presentation (4 results)

  • [Journal Article] Oral cancer diagnosis via a ferrocenylnaphthalene diimide-based electrochemica telomerase assay2013

    • Author(s)
      Mori K, Sato S, Kodama M, Habu M, Takahashi O, Nishihara T, Tominaga K, Takenaka S
    • Journal Title

      Chin Chem

      Volume: 59 Pages: 289-295

  • [Journal Article] Mechanisms of G1 cell cycle arrest and apoptosis in myeloma cells induced by hybrid-compound histone deacetylase inhibitor2013

    • Author(s)
      Fujii, S., Okinaga, T., Ariyoshi, W., Takahashi, O., Iwanaga, K., Nishino, N., Tominaga, K., Nishihara, T
    • Journal Title

      Biochem Biophys Res Commun434

      Volume: 3 Pages: 413-20

  • [Journal Article] Novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction in oral squamous cell carcinoma2011

    • Author(s)
      Takahashi,O.,Okinaga,T.,Iwanaga,K., Habu,M., Ariyoshi,W.,Tominaga,K. Nishino,N and Nishihara,T
    • Journal Title

      Journal of Biophysical Chemistry

      Volume: Vol.2, No.3 Pages: 215-221

  • [Journal Article] Inhibition of adjuvant arthritis in rats by electroporation with interleukin-1 receptor antagonist2011

    • Author(s)
      Sukedai,M., Ariyoshi, W., Okinaga, T, K. Iwanaga, M. Habu, I. Yoshioka, K. Tominaga, T. Nishihara
    • Journal Title

      J. Interferon and Cytokine Res.

      Volume: Nov;31(11) Pages: 839-46

  • [Presentation] ナノ・マイクロバブルと超音波を利用したドラッグデリバリーシステムの確立2013

    • Author(s)
      岩永賢二郎,沖永敏則,山本雅史,西原達次,冨永和宏
    • Organizer
      第73回九州歯科学会総会
    • Place of Presentation
      北九州
    • Year and Date
      2013-05-19
  • [Presentation] ミエローマ細胞における新規ヒストン脱アセチル化阻害剤の効果2012

    • Author(s)
      藤井誠子,高橋理,岩永賢二郎,土生学,福田仁一,冨永和宏
    • Organizer
      第57回日本口腔外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-10-19
  • [Presentation] ナノバブルを利用した超音波遺伝子・ドラッグデリバリーシステムの確立2012

    • Author(s)
      岩永賢二郎
    • Organizer
      第72回九州歯科学会総会
    • Place of Presentation
      北九州
    • Year and Date
      2012-05-18
  • [Presentation] マウスミエローマ細胞株における新規ヒストン脱アセチル化阻害剤に対する感受性の違い2012

    • Author(s)
      藤井誠子,高橋理,岩永賢二郎,土生学,福田仁一,冨永和宏
    • Organizer
      第66回日本口腔科学会総会
    • Place of Presentation
      広島
    • Year and Date
      2012-05-18

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Published: 2014-08-29  

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