2013 Fiscal Year Final Research Report
Research on the marine sources for drug discovery in the tropical coral reef.
| Project/Area Number |
22406001
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Living organism molecular science
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAMIKOSHI Michio 東北薬科大学, 薬学部, 教授 (30189196)
UKAI Kazuyo 東北薬科大学, 薬学部, 助教 (60433512)
KOBAYASHI Hisayoshi 東京大学, 分子細胞生物学研究所, 助教 (80225531)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 調査研究 / 薬用海洋資源 / 熱帯サンゴ礁海域 |
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| Research Abstract |
We conducted the research on the marine sources for drug discovery in the Indonesian tropical coral reef. In 2010-2013, we collected invertebrates including marine sponges and tunicates based on Manado four times. In 2010 and 2011, we isolated fungi from the invertebrates. We performed the screening of the biological activities, such as an inhibition of the ubiquitin-proteasome system, cytotoxicity, and antimicrobial activity, in our laboratory. We succeeded in isolating new compounds that inhibited the proteasome, the E1 in the ubiquitin system, the deubiquitinating enzyme USP7 and suppressed atherosclerosis in vivo. Theses results were reported in meetings and journals.
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