2012 Fiscal Year Final Research Report
Elucidation of Odor Information Coding in Higher Olfactory Centers
| Project/Area Number |
22500303
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MIYASAKA Nobuhiko 独立行政法人理化学研究所, シナプス分子機構研究チーム, 副チームリーダー (70332335)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 嗅覚 / 神経回路 / 脳 / 軸索投射 / 遺伝子工学 / 動物行動 / ゼブラフィッシュ |
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| Research Abstract |
In the olfactory system, odor information is represented as a topographic map of neural activities across glomeruli in the olfactory bulb (OB). However, it remains largely unknown how this odor map is transferred to higher brain centers. In the present study, I combined genetic single-neuron labeling and image registration techniques to address this issue in zebrafish. I found that 1) individual OB neurons send axons to multiple forebrain regions, and that 2) each target region receives either non-selective or biased projections from the OB with respect to glomerular classes. These results suggest that different forebrain regions sample distinct combinations of glomerular inputs and create various forms of olfactory representations.
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