Role of Drebrin in the regulation of ocular dominance plastiity

2012 Fiscal Year Final Research Report

• Project/Area Number: 22500311
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Maebashi Institute of Technology
• Principal Investigator: IMAMURA Kazuyuki 前橋工科大学, 工学部, 教授 (30203326)
• Co-Investigator(Kenkyū-buntansha): SHIRAO Tomoaki 群馬大学, 大学院・医学系研究科, 教授 (20171043)
• Project Period (FY): 2010 – 2012
• Keywords: 眼優位可塑性 / 視覚野 / ドレブリン / 中枢アミン系 / 免疫組織化学

Research Abstract

An unique activity-mapping method (cFAMM) was established to evaluate mouse ocular dominance (OD) plasticity. cFAMM was applied first to examine the effect of destruction of central aminergic system. It was found that noradr enaline (NA) and serotonergic (5HT) system differentially regulate OD plasticity. In drebrin-knockout mouse, the visual evoked expression of c-fos was suppressed as in the mice with NA-depletion, suggesting drebrin plays cruicial role in the regulation of OD plasticity.

Research Products

• [Journal Article] c-Fos activity mapping reveals differential effects of noradrenaline and serotonin depletion on the regulation of ocular dominance plasticity in rats (2013)
  • Author(s): Nakadate K., Imamura K., Wanatanbe Y
  • Journal Title: Neurosci Volume: 235 Pages: 1-9
  • URL: http://dx.doi.org/10.1016/j.neuroscience.2013.01.013
  • Peer Reviewed
• [Journal Article] Regulation of AMPAreceptor recruitment by the actin binding protein drebrin in cultured hippocampal neurons (2013)
  • Author(s): Kato K., Shirao T., Yamazaki H., Imamura K., Sekino Y
  • Journal Title: J. Neurosci. Neuroengin. Volume: 1 Pages: 153-160
  • DOI: DOI:10.1166/jnsne.2012.1018
  • Peer Reviewed
• [Journal Article] Effects of monocular deprivation on the spatial pattern of visually induced expression of c-Fos protein (2012)
  • Author(s): Nakadate K., Imamura K., Watanabe Y.
  • Journal Title: Neurosci Volume: 202 Pages: 17-28
  • DOI: DOI:10.1016/j.neuroscience.2011.12.004
  • Peer Reviewed
• [Journal Article] An alteration in the lateral geniculate nucleus of experimental glaucoma monkeys: In vivo positoron emission tomography imaging of glial activation (2012)
  • Author(s): Shimazawa M., Ito Y., Inokuchi Y., Yamanaka H., Hayashi T., Jin B., Higuchi M., Suhara T., Imamura K., Araie M., Watanabe Y., Onoe H., Hara H
  • Journal Title: PLoS one Volume: 7(1) Pages: 1-14
  • DOI: DOI:10.1371/journal.pone.0030526
  • Peer Reviewed
• [Presentation] Evaluation of non-alcohol beer intake by elevated plus-maze (2013)
  • Author(s): T. Kobayashi, H. Murayama, K. Imamura
  • Organizer: The Journal of Physiological Sciences
  • Place of Presentation: タワーホール船堀、東京都
  • Year and Date: 2013-03-29
• [Presentation] Involvement of drebrin, an actin binding protein, in regulation of AMPA receptor recruitment in cultured hippocampal neurons (2011)
  • Author(s): K. Kato, K. Imamura and Y. Sekino
  • Organizer: International radiation neurobiology
  • Place of Presentation: 群馬大学医学部刀城会館、群馬県
  • Year and Date: 2011-01-29
• [Presentation] Ocular dominance plasticity in abnormally developed visual cortex (2011)
  • Author(s): K. Imamura
  • Organizer: International radiation neurobiology
  • Place of Presentation: 群馬大学医学部刀城会館、群馬県
  • Year and Date: 2011-01-29
• [Book] Central changes in glaucoma: neuroscientific study using animal models (2011)
  • Author(s): Imamura K., Shimazawa M., Onoe H., Watanabe Y., Ishii, K., Mayama C., Akasaki T., Shimegi S., Sato, H., Nakadate, K., Hara H., Araie M
  • Total Pages: 307-330
  • Publisher: THE MISTERY OF GLAUCOMA, Kofronova M. and Kubena T. eds. INTEC
• [Remarks]
  • URL: http:// www.maebashi-it.ac.jp/~imamurak/