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2012 Fiscal Year Final Research Report

Role of Drebrin in the regulation of ocular dominance plastiity

Research Project

  • PDF
Project/Area Number 22500311
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionMaebashi Institute of Technology

Principal Investigator

IMAMURA Kazuyuki  前橋工科大学, 工学部, 教授 (30203326)

Co-Investigator(Kenkyū-buntansha) SHIRAO Tomoaki  群馬大学, 大学院・医学系研究科, 教授 (20171043)
Project Period (FY) 2010 – 2012
Keywords眼優位可塑性 / 視覚野 / ドレブリン / 中枢アミン系 / 免疫組織化学
Research Abstract

An unique activity-mapping method (cFAMM) was established to evaluate mouse ocular dominance (OD) plasticity. cFAMM was applied first to examine the effect of destruction of central aminergic system. It was found that noradr enaline (NA) and serotonergic (5HT) system differentially regulate OD plasticity. In drebrin-knockout mouse, the visual evoked expression of c-fos was suppressed as in the mice with NA-depletion, suggesting drebrin plays cruicial role in the regulation of OD plasticity.

  • Research Products

    (9 results)

All 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (3 results) Book (1 results) Remarks (1 results)

  • [Journal Article] c-Fos activity mapping reveals differential effects of noradrenaline and serotonin depletion on the regulation of ocular dominance plasticity in rats2013

    • Author(s)
      Nakadate K., Imamura K., Wanatanbe Y
    • Journal Title

      Neurosci

      Volume: 235 Pages: 1-9

    • URL

      http://dx.doi.org/10.1016/j.neuroscience.2013.01.013

    • Peer Reviewed
  • [Journal Article] Regulation of AMPAreceptor recruitment by the actin binding protein drebrin in cultured hippocampal neurons2013

    • Author(s)
      Kato K., Shirao T., Yamazaki H., Imamura K., Sekino Y
    • Journal Title

      J. Neurosci. Neuroengin.

      Volume: 1 Pages: 153-160

    • DOI

      DOI:10.1166/jnsne.2012.1018

    • Peer Reviewed
  • [Journal Article] Effects of monocular deprivation on the spatial pattern of visually induced expression of c-Fos protein2012

    • Author(s)
      Nakadate K., Imamura K., Watanabe Y.
    • Journal Title

      Neurosci

      Volume: 202 Pages: 17-28

    • DOI

      DOI:10.1016/j.neuroscience.2011.12.004

    • Peer Reviewed
  • [Journal Article] An alteration in the lateral geniculate nucleus of experimental glaucoma monkeys: In vivo positoron emission tomography imaging of glial activation2012

    • Author(s)
      Shimazawa M., Ito Y., Inokuchi Y., Yamanaka H., Hayashi T., Jin B., Higuchi M., Suhara T., Imamura K., Araie M., Watanabe Y., Onoe H., Hara H
    • Journal Title

      PLoS one

      Volume: 7(1) Pages: 1-14

    • DOI

      DOI:10.1371/journal.pone.0030526

    • Peer Reviewed
  • [Presentation] Evaluation of non-alcohol beer intake by elevated plus-maze2013

    • Author(s)
      T. Kobayashi, H. Murayama, K. Imamura
    • Organizer
      The Journal of Physiological Sciences
    • Place of Presentation
      タワーホール船堀、東京都
    • Year and Date
      2013-03-29
  • [Presentation] Involvement of drebrin, an actin binding protein, in regulation of AMPA receptor recruitment in cultured hippocampal neurons2011

    • Author(s)
      K. Kato, K. Imamura and Y. Sekino
    • Organizer
      International radiation neurobiology
    • Place of Presentation
      群馬大学医学部刀城会館、群馬県
    • Year and Date
      2011-01-29
  • [Presentation] Ocular dominance plasticity in abnormally developed visual cortex2011

    • Author(s)
      K. Imamura
    • Organizer
      International radiation neurobiology
    • Place of Presentation
      群馬大学医学部刀城会館、群馬県
    • Year and Date
      2011-01-29
  • [Book] Central changes in glaucoma: neuroscientific study using animal models2011

    • Author(s)
      Imamura K., Shimazawa M., Onoe H., Watanabe Y., Ishii, K., Mayama C., Akasaki T., Shimegi S., Sato, H., Nakadate, K., Hara H., Araie M
    • Total Pages
      307-330
    • Publisher
      THE MISTERY OF GLAUCOMA, Kofronova M. and Kubena T. eds. INTEC
  • [Remarks]

    • URL

      http:// www.maebashi-it.ac.jp/~imamurak/

URL: 

Published: 2014-08-29  

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