2012 Fiscal Year Final Research Report
Understanding of regulatory mechanism of motor activity using D1 and D2 dopamine receptor gene-modified mice
| Project/Area Number |
22500343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKUBO Tadashi 北里大学, 医学部, 准教授 (10450719)
SATO Asako 北里大学, 医学部, 臨時職員(研究員) (10465932)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ドーパミン受容体 / 遺伝子操作マウス / パーキンソン病 / 運動調節 / 協調運動 / 学習記憶 / 遺伝子工学 |
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| Research Abstract |
In Parkinson disease the degeneration of nigro-striatal dopamine neuron leads to depletion of dopamine and motor deficit. It is known that D1 and D2 dopamine receptors (D1R, D2R) expressed in the medium spiny neurons of striatum are involved to motor control. However, the regulatory mechanism of motor control via D1R and D2R remains to be clarified. In this study we found the conditional D1R-expressing mice controlled by Tet-off system showed decrease of motor activity in the homecage when D1R expression was suppressed in adult stage. This finding was opposite to the marked increase of motor activity of D1R KO mice. These suggest the presence or absence of D1R expression during mouse development is closely related to up-regulation or down-regulation of motor activity in adult stage.
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[Journal Article] PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus2012
Author(s)
hibasaki, T., Tokunaga, A., Sakamoto, R., Sagara, H., Noguchi, S., Sasaoka, T., and Yoshida, N
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Journal Title
Cerebral Cortex
Volume: online
DOI
Peer Reviewed
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[Journal Article] Methyl CpG-binding protein isoform MeCP2_e2 is dispensable for Rett syndrome phenotypes but essential for embryo viability and placenta development2012
Author(s)
Itoh, M., Tahimic, C.G.T., Ide,S., Otsuki, A., Sasaoka, T., Noguchi, S., Oshimura, M., Goto, Y., and Kurimasa, A
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Journal Title
Journal of Biological Chemistry
Volume: 287(17)
Pages: 13859-13867
DOI
Peer Reviewed
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[Journal Article] Abnormal epithelial cell polarity and ectopic epidermal growth factor receptor (EGFR) expression induced in Emx2 KO embryonic gonads2010
Author(s)
Kusaka, M., Katoh-Fukui, Y., Ogawa,H., Miyabayashi, K., Baba, T., Shima,Y., Sugiyama, N., Sugimoto, Y., Okuno, Y., Kodama, R., Iizuka-Kogo, A., Senda, T., Sasaoka, T., Kitamura, K., Aizawa, S., and Morohashi, K.-I
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Journal Title
Endocrinology
Volume: 151
Pages: 5893-5904
DOI
Peer Reviewed
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