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2012 Fiscal Year Final Research Report

Analysis of molecular integration by basal membrane in synapse formation and maintenance.

Research Project

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Project/Area Number 22500356
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionKyoto University

Principal Investigator

HOSOKAWA Hiroshi  京都大学, 大学院・情報学研究科, 講師 (90359779)

Project Period (FY) 2010 – 2012
Keywordsニューロン / シナプス / 神経回路 / 基底膜
Research Abstract

A physiological roles of molecular integration in synapse was studied by analysis of MAGI1 which indirectly binds to basal membrane. Biochemical and histochemical analysis revealed that MAGI1 was expressed in neuronal cells and localized on post synapse in brain. MAGI1 knockout mice showed abnormal anxiety -like and attention behaviour. In conlusion, molecular integration was required for normal synapse function and behavior.

  • Research Products

    (4 results)

All 2013 2011

All Journal Article (4 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Intragastric administration of allyl isothiocyanate reduces hyperglycemia in intraperitoneal glucose tolerance test (IPGTT) by enhancing blood glucose consumption in mice.2013

    • Author(s)
      Mori N, Kurata M, Yamazaki H, Hosokawa H, Nadamoto T, Inoue K, Fushiki T
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: 59 Pages: 56-63

    • Peer Reviewed
  • [Journal Article] The distribution of transient receptor potential melastatin-8in the rat soft palate, epiglottis, and pharynx.2013

    • Author(s)
      Sato T, Fujita M, Kano M, Hosokawa H, Kondo T, Suzuki T, Kasahara E, Shoji N, Sasano T, Ichikawa H.
    • Journal Title

      Cell Mol Neurobiol

      Volume: 33 Pages: 161-5

    • DOI

      doi:10.1007/s10571-012-9888-1.Epub2012Nov7.

    • Peer Reviewed
  • [Journal Article] Intragastric administration of allyl isothiocyanate increases carbohydrate oxidation via TRPV1 but not TRPA1 in mice.2011

    • Author(s)
      Mori N, Kawabata F, Matsumura S, Hosokawa H, Kobayashi S, Inoue K, Fushiki T
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 300 Pages: 494-505

  • [Journal Article] Cooling-sensitive TRPM8 is thermostat of skin temperature against cooling.2011

    • Author(s)
      Tajino K, Hosokawa H, Maegawa S, Matsumura K, Dhaka A, Kobayashi S.
    • Journal Title

      PLoS One

      Volume: 6 Pages: e17504

URL: 

Published: 2014-08-29  

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