2012 Fiscal Year Final Research Report
Analysis of the inflammatory mechanisms caused by the Ali18 mutation in molecular and cellular levels
| Project/Area Number |
22500392
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Tokai University |
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Principal Investigator |
ABE Koichiro 東海大学, 医学部, 講師 (90294123)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAMATSU Nobuhiko 北里大学, 理学部, 教授 (40206876)
ITO Michihiko 北里大学, 理学部, 准教授 (90240994)
KIMURA Minoru 東海大学, 医学部, 教授 (10146706)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 疾患モデル |
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| Research Abstract |
The Ali18 mutation in an kinase gene causes inflammatory arthritis in mice. However, its molecular mechanisms remains largely unknown. Here we show that Ali18; W/Wv double mutant mice show no inflammatory arthritis. These results indicate the effects of the Ali18 mutation on mast cells trigger the initiation of inflammation.
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[Journal Article] Hrabe de Angelis M. A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cg2 causes inflammatory arthritis, metabolic defects, and male fertility in vitro in a murine model2011
Author(s)
阿部幸一郎, Fuchs H, Boersma A, Hans W, Yu P, Kalaydjiev, Klaften M, Adler T, Calazada-Wack, Mossbrugger I, Rathkolb B, Rozman J, Prehn C, Maraslioglu M, Kametani Y, Shimada S, Adamski J, Busch DH, Esposito I, Kingenspor M, Wolf E, Wurst W, Gailus-Durner V, Ka
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Journal Title
Arthritis & Rheumatism
Volume: 63
Pages: 1301-1311
DOI
Peer Reviewed
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[Presentation] ホスホリパーゼCγ2 の新規機能亢進型変異であるAli14はマウスにおいて炎症性関節炎を引き起こす2010
Author(s)
阿部幸一郎, Fuchs H, Boersma A, Yu P, Kalaydjiev S, Klaften M, Adler T, Hans W, Rathkolb B, Prehn C, Adamski J, Busch D, Wolf E, Gailus-Druner, Katan M, Marschall S, Wagner S, Hrabe de Angelis M
Organizer
日本実験動物学会総会
Place of Presentation
京都
Year and Date
2010-05-12
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