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2012 Fiscal Year Final Research Report

Study on improvement of microfluidic chips for isolation of rare circulating tumor cells in blood.

Research Project

  • PDF
Project/Area Number 22500422
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionToyama Industrial Technology Center,

Principal Investigator

OHNAGA Takashi  富山県工業技術センター, 中央研究所, 研究員 (10416133)

Co-Investigator(Renkei-kenkyūsha) SHIMADA Yutaka  富山大学, 大学院医学薬学研究部, 准教授 (30216072)
KISHI Hiroyuki  富山大学, 大学院医学薬学研究部, 准教授 (60186210)
OBATA Tsutomu  富山県工業技術センター, 中央研究所, 研究員 (30416143)
Project Period (FY) 2010 – 2012
Keywords生体情報・計測 / 腫瘍細胞 / マイクロ流体チップ
Research Abstract

We developed polymeric microfluidic chips for isolation of rare circulating tumor cells (CTCs) in blood. The chips exhibited capture efficiency more than 90% owing to their specific surface functionality. Cost and productivity of the chip were so practical that the chips have been commercially available at a price less than one tenth of that of the conventional chips. CTCs from patient blood were confirmed to be captured with the chip.

  • Research Products

    (10 results)

All 2013 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article]

    • Author(s)
      大永崇、嶋田裕、森山亮仁、岸裕幸、小幡勤、高田耕児、奥村知之、長田拓哉、村口篤、塚田一博
    • Journal Title

      Biomedical Microdevices

    • DOI

      DOI:10.1007/s10544-013-9775-7

    • Peer Reviewed
  • [Presentation] 細胞表面マーカーがCTC単離用ポリマーマイクロ流体デバイスの捕捉効率に及ぼす影響2013

    • Author(s)
      大永崇、嶋田裕
    • Organizer
      第72回日本癌学会学術総会
    • Year and Date
      2013-10-03
  • [Presentation] 安価で簡便なデバイスシステムによるcirculating tumor cells(CTC)検出の試み2013

    • Author(s)
      森山亮仁、嶋田裕
    • Organizer
      第113回日本外科学会定期学術集会
    • Year and Date
      2013-04-13
  • [Presentation] 循環腫瘍細胞を単離するためのポリマーマイクロ流体デバイスによる癌細胞株の効率的捕捉2012

    • Author(s)
      大永崇、嶋田裕
    • Organizer
      第71回日本癌学会学術総会
    • Year and Date
      2012-09-20
  • [Presentation] New micro-fluidic devices with polymeric materials for isolation of circulating tumor cells.2012

    • Author(s)
      Yutaka Shimada, Takashi Ohnaga
    • Organizer
      The 103rd Annual Meeting of the American Association for Cancer Research
    • Year and Date
      2012-04-02
  • [Presentation] Micro-Fluidic Devices Advanced with Polymeric Materials for Isolation of Circulating Tumor Cells.2011

    • Author(s)
      Takashi Ohnaga, Tsutomu Obata, Hiroyuki Kishi, Yutaka Shimada, Kazuhiro Tsukada
    • Organizer
      8th International Symposium
    • Place of Presentation
      Minimal Residual Cancer
    • Year and Date
      2011-09-22
  • [Presentation] 細胞スクリーニングのための微細構造を有するポリマーマイクロチップ2011

    • Author(s)
      大永崇
    • Organizer
      第29回日本ヒト細胞学会学術集会
    • Year and Date
      2011-08-20
  • [Remarks]

    • URL

      http://www.itc.pref.toyama.jp/reserch/report/2011/r2011_2_019.pdf

  • [Patent(Industrial Property Rights)] 血液中の浮遊癌細胞を捕捉できるマイクロチップ2011

    • Inventor(s)
      大永崇、小幡勤、高田耕児、村口篤、岸裕幸、嶋田裕、塚田一博
    • Industrial Property Rights Holder
      富山県、富山大学
    • Industrial Property Number
      特許,特願2011-164897
    • Filing Date
      2011-07-28
  • [Patent(Industrial Property Rights)] マイクロリアクタ2011

    • Inventor(s)
      大永崇
    • Industrial Property Rights Holder
      富山県
    • Industrial Property Number
      特許,特願2011-055871
    • Filing Date
      2011-03-14

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Published: 2014-08-29  

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