Clinical application of preload stress echocardiography with leg-positive pressure in patients with chronic heart failure

2013 Fiscal Year Final Research Report

• Project/Area Number: 22500437
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: The University of Tokushima
• Principal Investigator: YAMADA Hirotsugu 徳島大学, 大学病院, 講師 (40380084)
• Co-Investigator(Kenkyū-buntansha): KUSUNOSE Kenya 徳島大学, 病院, 助教 (70507649) ; TOMITA Noriko 徳島大学, 病院, 医員 (10533127)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Keywords: 心エコードプラ法 / 慢性心不全 / 僧帽弁口血流速波形 / 左室拡張末期圧 / 左室拡張不全 / 予後

Research Abstract

Preload stress echocardiography was applied with leg-positive pressure (LPP) in patients with mild heart failure. Patients were classified into 3 groups based on transmitral flow velocity pattern: restrictive or pseudontrmal (PN) at rest, impaired relaxation (IR) at rest and during LPP (stable IR), and IR at rest and PN during LPP (unstable IR). All-cause cardiac event rate was higher in unstable IR than in stable IR, and was similar in PN group. Event-free survival was lower in unstable IR than stable IR. Preload stress echocardiography provides additional prognostic information in mild heart failure patients beyond conventional echocardiographic parameters.

Research Products

• [Journal Article] Utility of lower limb positive pressure test for diagnosis of diastolic heart failure : a case report (2014)
  • Author(s): Hara T, Kishi-Tanaka K, Iwase T, Yamada H, Akaike M, Sata M
  • Journal Title: J Med Invest Volume: (in press)
  • Peer Reviewed
• [Journal Article] Preload Stress Echocardiography for Predicting the Prognosis of Patients With Mild Heart Failure (2014)
  • Author(s): Yamada H, Kusunose K, Nishio S, Bando M, Hotchi J, Hayashi S, Takayuki I, Yagi S, Yamaguchi K, Iwase T, Soeki T, Wakatsuki T, Sata M
  • Journal Title: 2014 J Am Col Cardiol Volume: (in press)
  • Peer Reviewed
• [Presentation] Effect of Aging and Gender on Tricuspid Annular Motion Velocities and Displacement (2013)
  • Author(s): Yamada H, Nishio S, Hayashi S, Hotchi J, Bando M, Hirata Y, Tomofuji T, Sata M
  • Organizer: ASE 2013 scientific session American Society of Echocarodiography
  • Place of Presentation: Minneapolis Convention Center (USA, Minneapolis)
  • Year and Date: 20130630-0703
• [Presentation] Clinical Significance of Mitral L-wave in Patients with Atrial Fibrillation and Preserved Ejection Fraction (2013)
  • Author(s): Nakagawa M, Yamada H, Nishio S, Hayashi S, Hotchi J, Bando M, Hirata Y, Tomofuji T, Sata M
  • Organizer: ASE 2013 scientific session American Society of Echocarodiography
  • Place of Presentation: Minneapolis Convention Center (USA, Minneapolis)
  • Year and Date: 20130630-0703
• [Presentation] Assessment of Optimal Method for Analysing Left Atrial Strain using Speckle Tracking Imaging (2013)
  • Author(s): Hayashi S, Yamada H, Hotchi J, Nishio S, Bando M, Hirata Y, Sata M
  • Organizer: ASE 2013 scientific session American Society of Echocarodiography
  • Place of Presentation: Minneapolis Convention Center (USA, Minneapolis)
  • Year and Date: 20130630-0703
• [Presentation] 心エコー・ドプラ法の臨床～Diastology 2013～ (2013)
  • Author(s): 山田博胤
  • Organizer: 第38回日本超音波検査学会学術集会
  • Place of Presentation: ひめぎんホール(愛媛県)
  • Year and Date: 20130614-16
• [Presentation] 僧帽弁輪運動速波形と推定中心血圧を用いた左室-動脈連関の臨床的評価 (2013)
  • Author(s): 林修司, 山田博胤, 發知淳子, 坂東美佳, 西尾進, 山尾雅美, 鳥居祐太, 平田有紀奈, 添木武, 佐田政隆
  • Organizer: 第86回日本超音波医学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 20130524-26
• [Presentation] 僧帽弁口血流速波形が偽正常化パターンを示す左室駆出率が保持された心不全(HFPEF)と左房機能不全の鑑別 (2012)
  • Author(s): 林修司, 山田博胤, 冨田紀子, 發知淳子, 坂東美佳, 西尾進, 玉井利奈, 中川摩耶, 弘田大智, 平田有紀奈, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆
  • Organizer: 第60回日本心臓病学会学術集会
  • Place of Presentation: 石川県立音楽堂(石川県)
  • Year and Date: 20120914-16
• [Presentation] Differentiation Between Hypertrophic Cardiomyopathy and Hypertensive Heart Disease Using Tricuspid Annular Motion Velocity (2012)
  • Author(s): Hayashi S, Yamada H, Tomita N, Hotchi J, Bando M, Nishio S, Tamai R, Nakagawa M, Ise T, Niki T, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Sata M
  • Organizer: American Society of Echocardiography 2012
  • Place of Presentation: Gaylord National(USA, National Harbor)
  • Year and Date: 20120630-0703
• [Presentation] Differentiation of Left Atrial Dysfunction From Pseudonormal/Restrictive Transmitral Flow Velocity Pattern in Patients With Preserved Ejection Fraction (2012)
  • Author(s): Hayashi S, Yamada H, Tomita N, Hotchi J, Bando M, Nishio S, Tamai R, Nakagawa M, Hirota D, Hirata Y, Sata M
  • Organizer: American Society of Echocardiography 2012
  • Place of Presentation: Gaylord National(USA, National Harbor)
  • Year and Date: 20120630-0703
• [Presentation] 僧帽弁輪運動速波刑を用いた左室駆出率が保持された心不全と心房機能不全の鑑別 (2012)
  • Author(s): 林修司, 山田博胤, 冨田紀子, 發知淳子, 坂東美佳, 西尾進, 玉井利奈, 弘田大智, 平田有紀奈, 佐田政隆
  • Organizer: 日本超音波医学会第85回学術集会
  • Place of Presentation: グランドプリンスホテル(東京都)
  • Year and Date: 20120525-27
• [Presentation] Transmitral Flow Velocity Pattern : Sometimes Old-fashioned Way is the Best Way.コントロバーシー7 :拡張能の指標として何が適切か (2012)
  • Author(s): Yamada H
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 20120316-18
• [Presentation] Prognostic Value of"Preload Stress Echocardiography"in Patients with Mild Heart Failure.プレナリーセッション6 (PL6)心エコー図診断の最新の知見と新たな展開 (2012)
  • Author(s): Yamada H, Tomita N, Hayashi S, Hotchi J, Nishio S, Tamai R, Niki T, Yamaguchi K, Iwase T, Taketani Y, Soeki T, Wakatsuki T, Sata M
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 20120316-18
• [Presentation] Tricuspid Annular Motion Velocity in Left Ventricular Hypertrophy : Comparison between Hypertensive Heart Disease and Hypertrophic Cardiomyopathy (2011)
  • Author(s): Hayashi S, Yamada H, Nishio S, Tomita N, Kusunose K, Endo K, Tamai R, Bando S, Hisaoka S, Takeuchi H, Niki T, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Akaike M, Sata M
  • Organizer: 第75回日本循環器学会総会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 20110803-04
• [Presentation] 特別演題企画「左室拡張機能評価法を整理して理解する」, TE-e'は左室拡張末期圧を反映する-下肢腸圧および硝酸薬負荷を用いた検討- (2011)
  • Author(s): 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 玉井利奈, 添木武, 赤池雅史, 佐田政隆
  • Organizer: 第84回日本超音波医学会学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京都)
  • Year and Date: 20110527-29
• [Presentation] 揺さぶってはじめて分かる心機能～さまざまな負荷心エコーの臨床応用～ (2011)
  • Author(s): 山田博胤
  • Organizer: 第21回日本超音波医学会四国地方会, 第10回四国地方会講習会教育講演
  • Place of Presentation: カルポート高知(高知県)
  • Year and Date: 2011-10-15
• [Presentation] 左室内同期不全に対する前負荷の影響拡張型心筋症における下肢陽圧負荷3次元心エコー法を用いた検討 (2011)
  • Author(s): 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 三木淳子, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆
  • Organizer: 先進血管エコー研究会
  • Place of Presentation: 新阪急ホテル(大阪府)
  • Year and Date: 2011-08-20